A nationwide clinical trial for a new type treatment that could offer help to those suffering from Duchenne Muscular Dystrophy, a devastating neuromuscular disease.
Researchers identify a protein trafficking defect within brain cells that may underlie common non-familial forms of Parkinson’s disease. The study implicates two genetic variants that disrupt protein sorting in neurons.
Researchers have identified specific cellular events that appear key to the debilitating autoimmune disease, lupus. The findings suggest that blocking this pathway in lupus-triggering cells could be a potent weapon against the disease.
Researchers identify a new gene associated with Hirschprung Disease and show how the migration of cells that form the gut nervous system is impeded when the combined doses of two candidate genes are low. Understanding the genetic basis of HSCR offers hope for better diagnostics and treatment for it and other developmental defects caused by failure of cell migration.
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A new study expands and deepens the biological and genetic links between cardiovascular disease and schizophrenia. Cardiovascular disease (CVD) is the leading cause of premature death among schizophrenia patients, who die from heart and blood vessel disorders at a rate double that of persons without the mental disorder.
Future research into the underlying causes of neurological disorders such as autism, epilepsy and schizophrenia, should greatly benefit from a first-of-its-kind atlas of gene-enhancers in the cerebrum (telencephalon). This new atlas identifies and locates thousands of gene-regulating elements in a region of the brain that is of critical importance for cognition, motor functions and emotion.
New research demonstrates how defects in an important neurological pathway in early development may be responsible for the onset of schizophrenia later in life.
New research concludes the eye, which depends on light to see, also needs light to develop normally during pregnancy.
Researchers have identified a new genetic mutation for amyotrophic lateral sclerosis (ALS), opening the door to future targeted therapies.
Scientists report researchers are now on the threshold of human application of stem cell therapies for a class of neurological diseases known as myelin disorders – a long list of diseases that include conditions such as multiple sclerosis, white matter stroke, cerebral palsy, certain dementias, and rare but fatal childhood disorders called pediatric leukodystrophies.
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Scientists have observed the neurological mechanism behind temperature-dependent febrile seizures by genetically engineering fruit flies to harbor a mutation analogous to one that causes epileptic seizures in people. Their new study also highlights the first use of genetic engineering to swap a human genetic disease mutation into a directly analogous gene in a fly.
Scientists studying a rare genetic disorder have identified a molecular pathway that may play a role in schizophrenia, according to new research. The findings may one day guide researchers to new treatment options for people with schizophrenia - a devastating disease that affects approximately 1 percent of the world's population.