GABA can selectively regulate the excitability of neurons.
Increased potassium currents were responsible for hyperactivity of CA3 neurons. When exposed to potassium channel blockers, the hyperactivity disappeared. However, when exposed to lithium, the drug not only reversed hyperactivity but reduced potassium currents at the same time. The findings strengthen the case that potassium currents play a role in bipolar disorder.
Researchers have identified a set of drug-like compounds, including a common ingredient in throat lozenges, that can help protect mitochondria from the stresses associated with neurodegenerative diseases.
A global knockout of the thrombin receptor PAR1 accelerates myelin development. The findings could help with the development of treatments for diseases associated with demyelination, like multiple sclerosis.
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Researchers have identified a circuit in the brains of fruit flies, which enables them to see in color. The network is similar to that which allows human color vision. The findings could help in the development of AI technologies.
Critical aspects of hippocampal function can be reversed in old age, or compensated for throughout life, with the help of neural stem cells.
Criticality in the brain was linked to inhibitory neurons imposing and organizing the computational dynamics.
Neurons in the pre-supplementary motor area play a critical role in visual search.
Inhibitory inputs to the neural circuit between the dorsolateral bed nucleus of the stria terminalis (dlBNST) to the ventral tegmental area (VTA) increase when a person is in chronic pain. This alteration is mediated by enhanced corticotropin-releasing factor signaling within the dlBNST, leading to suppression of the mesolimbic dopaminergic system. The result is depressive mood and anhedonia associated with chronic pain.