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          Autism

          Research articles covering work related to austism spectrum disorders are provided below.

          This shows a brain and DNA.
          AutismFeaturedGeneticsNeuroscience
          ·December 5, 2024·7 min read

          Missing Genetic Link Uncovered in Idiopathic Autism

          Researchers have uncovered a molecular mechanism linking alterations in the neuronal protein CPEB4 to idiopathic autism, which accounts for 80% of autism cases without a clear genetic cause. The study reveals that the absence of a specific microexon in CPEB4 disrupts the dynamics of molecular condensates in neurons, affecting the regulation of genes crucial for brain development. This disruption can lead to reduced protein production, impairing neuronal growth and function.
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          This shows a brain.
          AutismFeaturedGeneticsNeurosciencePsychology
          ·November 21, 2024·4 min read

          Immune System Gene Linked to Hyperactivity, ADHD and Autism

          Researchers have uncovered a link between the immune gene regulator STAT1 and hyperactive behaviors in mice, offering new insights into neurodevelopmental disorders like autism and ADHD. STAT1, vital for infection response, also influences brain cell activity, particularly dopamine neurons involved in motivation and learning. In mice with prolonged STAT1 signaling, hyperactivity and reduced neural activity in key brain regions were observed. The study opens the door to targeting STAT1 for potential therapies to address neurobehavioral disorders.
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          This shows a brain.
          AutismFeaturedGeneticsNeuroscience
          ·November 20, 2024·6 min read

          Gene Repair Restores Brain Signal Efficiency in Autism

          Autism-linked SHANK3 gene mutations disrupt not only neurons but also oligodendrocytes, essential for producing myelin, which insulates nerve fibers. This damage reduces brain signal efficiency and impairs behavior. Using gene therapy, researchers successfully repaired these cells in a mouse model, restoring their function and myelin production. They validated their findings with human-derived stem cells, confirming similar impairments and repair mechanisms.
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          This shows a pregnant woman with a mask on.
          AutismFeaturedNeuroscience
          ·November 13, 2024·3 min read

          Air Pollution Linked to Autism Risk During Developmental Stages

          A new review highlights how air pollution, particularly fine particles and nitrogen oxides, can elevate autism risk by disrupting critical brain development processes. Key mechanisms, including nitrosative stress, neuroinflammation, and neurotransmitter disruptions, reveal how prenatal and early childhood exposure impact neurological health. Small particles, such as PM2.5, can cross the placenta, potentially harming fetal brain development, especially for genetically predisposed individuals.
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          This shows people walking paths.
          AutismFeaturedNeuroscience
          ·October 31, 2024·4 min read

          How Autistic Traits Influence Exploration and Learning

          People with stronger autistic traits exhibit distinct and highly effective exploration patterns, according to a new study. These individuals tend to persist longer in curiosity-driven tasks, leading to better overall performance. In the study, participants with higher autistic traits explored consistently, even when faced with challenging learning environments, while those with lower traits engaged more briefly. This prolonged exploration allowed the higher-trait participants to achieve better learning outcomes.
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          This shows letters and a brain.
          AutismFeaturedNeuroscience
          ·October 25, 2024·8 min read

          Autistic Children’s Fascination with Letters Offers Learning Clues

          A recent study highlights that many autistic children show an intense interest in letters and numbers, which may play a distinct role in their language development. By analyzing clinical records and interviewing parents, researchers found that 37% of autistic children had a strong interest in letters, in contrast to just 3% of non-autistic peers. This interest often emerges around 30 months, aligning with typical development timelines but diverging in how it's applied.
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          This shows a brain.
          AutismFeaturedGeneticsNeuroscience
          ·October 24, 2024·6 min read

          In-Utero Gene Editing Could Halt Neurodevelopmental Disorders

          A new study has developed a breakthrough biomedical tool that can deliver genetic material to edit faulty genes in fetal brain cells. Tested in mice, this technology offers the potential to stop the progression of neurodevelopmental conditions, like Angelman and Rett syndromes, before birth.
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          This shows a brain and DNA.
          AutismFeaturedNeuroscience
          ·October 24, 2024·6 min read

          Stem Cell Mini-Brains Unlock Insights into Autism

          Researchers have created "mini-brains" using stem cells from patients with a rare form of autism, allowing them to study brain development in detail. These organoids revealed how a genetic mutation in MEF2C disrupts the balance between excitatory and inhibitory neurons, leading to autism.
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          This shows an empty crib.
          AutismFeaturedNeuroscience
          ·October 24, 2024·6 min read

          Infant Sleep Loss Linked to Brain Development Problems

          New research shows that sleep deprivation during early development disrupts brain function, impacting neuron growth and synapse formation. The study found that young mice lacking sleep did not experience the “sleep rebound” seen in adults, leading to lasting deficits in social behavior and memory.
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          This shows a brain.
          AutismFeaturedNeuroscience
          ·October 22, 2024·3 min read

          Cerebellum Plays Key Role in Social and Cognitive Abilities

          The cerebellum, traditionally linked to motor functions, also plays a vital role in social and cognitive abilities, according to new research. Abnormalities in this brain region not only impair movement but are linked to emotional and behavioral issues, particularly in autism.
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          This shows a brain.
          AutismFeaturedGeneticsNeuroscience
          ·October 18, 2024·4 min read

          Autism Risk in Males Linked to Y Chromosome

          New research suggests that the Y chromosome may be responsible for the higher prevalence of autism in males, shifting focus away from protective factors on the X chromosome. Analyzing genetic data, researchers found that individuals with an additional Y chromosome were twice as likely to have an autism diagnosis, while an extra X chromosome had no effect on autism risk.
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          This shows a pregnant woman and a brain.
          AutismFeaturedNeuroscience
          ·October 17, 2024·4 min read

          Folic Acid Reduces Lead’s Impact on Autism Risk

          A study has shown that folic acid supplementation during pregnancy may reduce the link between maternal blood lead levels and autistic-like behaviors in children. By examining data from pregnant women and their toddlers, researchers found stronger associations between lead exposure and autism traits in cases of low folic acid intake.
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          This shows a neuron.

          Brain Taps Lipid Stores for Energy During Activity

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          Universally Cool: Personality Traits That Cross Cultural Lines

          This shows an older woman.

          Aging Brain May Adapt to Decode Tricky Social Cues

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          Clearing Brain Sugar Stores Could Protect Against Dementia

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