A newly developed immuno-infrared sensor allowed researchers to discover biomarkers for Alzheimer's disease in blood samples 17 years before clinical symptoms appeared. The sensory is able to detect the misfolding of amyloid beta.
A new mouse study reveals our sleep position may influence the glymphatic system and could increase the risk of developing ALS or other neurodegenerative diseases.
Mislocalization of the TDP-43 protein alters the genetic instructions for UNC13A. The findings provide a potential new therapeutic target for the treatment of ALS and frontotemporal dementia.
Findings point to microglial TREM2 as a potential target for the treatment of ALS.
A novel method detected conformational changes to the TDP-43 protein in cerebral spinal fluid associated with ALS.
c9ASO, an investigational ASO drug, targets the TDP-43 protein, reducing its buildup and decreasing neurological decline associated with ALS and FTD.
Researchers identified a group of closely related genes that capture molecular links between Alzheimer's and LATE, a common brain disorder that mimics Alzheimer's symptoms.
Study reports protein aggregates within cells are cleared out by the endocytosis process. The findings could help with the development of new treatments for ALS.
A new hypothesis suggests declining rates of dementia could be a result of generational differences in lifetime exposure to lead.
LATE, a form of dementia that appears in the oldest-old is often mistaken for Alzheimer's disease, but the brain pathology is very different. The protein TDP-43 appears to play a significant role in the development of LATE. The neurodegenerative disease may progress more gradually than Alzheimer's, but when combined with Alzheimer's disease (a common combination), appears to cause a more rapid decline than either would alone.
Researchers have identified the gene STMN2 as a novel biomarker and potential drug target for ALS.
A new study reveals many inhibitory neurons are lost in early phases of ALS and FTD development. The findings show a contrast to other neurodegenerative diseases where excitatory neurons are lost early in the disorders.
