A novel method detected conformational changes to the TDP-43 protein in cerebral spinal fluid associated with ALS. Read More
c9ASO, an investigational ASO drug, targets the TDP-43 protein, reducing its buildup and decreasing neurological decline associated with ALS and FTD. Read More
Researchers identified a group of closely related genes that capture molecular links between Alzheimer's and LATE, a common brain disorder that mimics Alzheimer's symptoms. Read More
Study reports protein aggregates within cells are cleared out by the endocytosis process. The findings could help with the development of new treatments for ALS. Read More
A new hypothesis suggests declining rates of dementia could be a result of generational differences in lifetime exposure to lead. Read More
LATE, a form of dementia that appears in the oldest-old is often mistaken for Alzheimer's disease, but the brain pathology is very different. The protein TDP-43 appears to play a significant role in the development of LATE. The neurodegenerative disease may progress more gradually than Alzheimer's, but when combined with Alzheimer's disease (a common combination), appears to cause a more rapid decline than either would alone. Read More
Researchers have identified the gene STMN2 as a novel biomarker and potential drug target for ALS. Read More
A new study reveals many inhibitory neurons are lost in early phases of ALS and FTD development. The findings show a contrast to other neurodegenerative diseases where excitatory neurons are lost early in the disorders. Read More
A new study sheds light on the molecular mechanisms behind ALS. Read More
Researchers report microglia is critical for neuronal survival in ALS. Read More
A new mouse model has been developed that captures the pathology of sporadic neurodegenerative diseases. Read More
Researchers have identified a genetic mutation associated with both ALS and frontotemporal dementia. Read More
