TDP-43

Featured Genetics Neurology Neuroscience

·February 11, 2020

Speeding up treatments for ALS

Study reports protein aggregates within cells are cleared out by the endocytosis process. The findings could help with the development of new treatments for ALS. Read More

Featured Neurology Neuroscience

·December 19, 2019

Is there a link between lifetime lead exposure and dementia?

A new hypothesis suggests declining rates of dementia could be a result of generational differences in lifetime exposure to lead. Read More

This shows someone holding an old person's hands

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·April 30, 2019

When is Alzheimer’s not Alzheimer’s? Researchers characterize a different form of dementia

LATE, a form of dementia that appears in the oldest-old is often mistaken for Alzheimer's disease, but the brain pathology is very different. The protein TDP-43 appears to play a significant role in the development of LATE. The neurodegenerative disease may progress more gradually than Alzheimer's, but when combined with Alzheimer's disease (a common combination), appears to cause a more rapid decline than either would alone. Read More

Featured Genetics Neurology

·January 15, 2019

Potential Therapeutic Target for ALS Revealed

Researchers have identified the gene STMN2 as a novel biomarker and potential drug target for ALS. Read More

Featured Genetics Neurology

·March 22, 2018

Focusing on Early Stage of Illness May Be Key to Treating ALS

A new study reveals many inhibitory neurons are lost in early phases of ALS and FTD development. The findings show a contrast to other neurodegenerative diseases where excitatory neurons are lost early in the disorders. Read More