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stem cells

Featured Genetics Neurology Neuroscience Pain

·January 25, 2020·2 min read

First treatment for pain using human stem cells a success

Transplanting GABAergic cells derived from human-induced pluripotent stem cells into mice resulted in safe, lasting, and effective relief from extreme neuropathic pain. Researchers hope to begin human testing within five years.

Featured Genetics Neuroscience Psychology

·January 22, 2020·5 min read

How stress causes gray hair

Study reveals a link between the nervous system and stem cells that regenerate pigment in hair follicles. When stressed, norepinephrine from the sympathetic nervous system causes melanocyte stem cells to activate excessively. The stem cells all convert into pigment-producing cells, prematurely depleting the reservoir. The findings explain the cellular and molecular links between stress and premature hair graying.

Featured Genetics Neuroscience

·January 20, 2020·2 min read

A new role for neurogenesis

Dentate gyrus neurogenesis acts to replace lost neurons and restore function following massive neuron loss.

Electrophysiology Featured Genetics Neuroscience Open Neuroscience Articles

·January 9, 2020·4 min read

Rejuvenating the brain: More stem cells improve learning and memory of old mice

Critical aspects of hippocampal function can be reversed in old age, or compensated for throughout life, with the help of neural stem cells.

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·September 16, 2019·5 min read

Transplanted brain stem cells survive without anti-rejection drugs

Researchers have developed a new method to transplant neural stem cells into mice without the need for lifelong anti-rejection medications.

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·September 16, 2019·4 min read

Alzheimer’s disease risk gene APOE4 impairs function of brain immune cells

APOE4 increases the inflammatory response of human microglia while reducing cellular migration. The gene also impairs the metabolic activity of the immune cells. The findings show APOE4 has a profound impact on the basic functions of microglia.

Featured Genetics Neuroscience Open Neuroscience Articles Psychology

·September 14, 2019·4 min read

Scientists identify gene as master regulator in schizophrenia

TCF4 may serve as a master regulator of a gene network dysregulated in schizophrenia at the early stages of neurodevelopment.

Featured Genetics Neurology Neuroscience

·August 30, 2019·4 min read

Creation of new brain cells plays an underappreciated role in Alzheimer’s disease

Microglia may play a significant role in disrupting neurogenesis in those with Alzheimer's disease. When mice were given drugs which caused microglial cells to die, neurogenesis returned to normal.

This shows cells from the clock in a dish

Featured Genetics Neuroscience Neuroscience Videos Open Neuroscience Articles

·August 29, 2019·4 min read

Human developmental clock mimicked in a dish

The human development 'clock in a dish' opens up new avenues for research and provides a way to replicate developmental disorders.

This shows Id4 expression in hippocampal neurons

Featured Genetics Neuroscience Open Neuroscience Articles

·August 29, 2019·3 min read

Signal blocks stem cell division in the geriatric brain

A gene regulated called Id4 appears to be a key component in controlling stem cell proliferation.

Brain Cancer Featured Neurology Neuroscience

·August 27, 2019·4 min read

Researchers take aim at circadian clock in deadly brain cancer

Glioblastoma stem cells' circadian clocks ramp up the cells' metabolism, making them stronger, more resistant to treatment, and able to divide and multiply more rapidly. By targeting the stem cells with a small molecule drug, researchers found mice models lived longer and their tumors shrank.