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SOD1

Featured Genetics Neurology Neuroscience

·October 15, 2024·6 min read

Toxic Protein May Uniquely Affect Brain, Spine, and Muscles in ALS

A recent study reveals that the toxic trimer form of the protein SOD1 affects the brain, spinal cord, and muscle tissues differently in ALS, shedding light on its complex progression. The study found SOD1 trimers bind uniquely to different proteins in each tissue type, potentially impacting cellular communication, structure, and energy production. For instance, SOD1 trimers in neurons affect cellular aging and communication, while in muscle cells, they disrupt metabolic processes.

Featured Genetics Neurology Neuroscience

·August 13, 2022·3 min read

‘Abnormal’ Protein Could Be Common Link Between All Forms of Motor Neuron Disease

A new study reports that abnormalities in the SOD1 protein are a common factor in all types of motor neuron diseases.

Featured Neurology Neuroscience Open Neuroscience Articles

·March 18, 2022·5 min read

Could There Be a Link Between the Enteric Neurons, Gut Microbiome and ALS?

Study reveals an association between intestinal inflammation and the gut microbiome in the development and progression of ALS.

Featured Neurology Open Neuroscience Articles

·September 3, 2020·4 min read

Promising New ALS Drug Candidates

Ebselen, a Selenium-based drug molecule, and several other novel compounds can change the characteristics of SOD1. The findings could help with the development of new therapeutics for ALS.

Featured Neurology Open Neuroscience Articles

·August 12, 2020·4 min read

Researchers Utilize Human-On-A-Chip Approach to Model ALS Pathology

Human-on-a-chip technology could provide a more valuable clinical-based model for ALS.

Featured Genetics Neurology Neuroscience

·April 20, 2020·5 min read

Researchers delay onset of ALS

Increasing the activity of interneurons in later 5 of the primary motor cortex in mouse models of ALS effectively slowed the onset of the disease.

Featured Genetics Neurology Neuroscience

·March 27, 2020·6 min read

Gene that first slows, then accelerates, progression of ALS in mice identified

The TBK1 gene regulates the disease progression of ALS in mouse models of the neurodegenerative disease. Loss of the TBK1 gene in motor neurons increases SOD1 aggregation and accelerates the onset of the disease.

Featured Neurology Neuroscience Open Neuroscience Articles

·September 17, 2019·4 min read

Environmental toxin produced by algae may lead to ALS

Exposure to the environmental toxin BMAA may elevate the risk of ALS. BMAA is produced by cyanobacteria, a blue-green alga that commonly occurs in marine ecosystems and accumulates in shellfish, sharks, and other sea-life. Those most reliant on sea-foods for their food source may be most at risk.

Featured Neurology Neuroscience

·July 22, 2019·5 min read

Gut microbes may affect the course of ALS

Researchers have isolated a molecule that may be under-produced in the gut of those with ALS. Using mouse models of the disease, researchers identified 11 microbial strains that became altered as the disease progressed, or before the development of symptoms.

Featured Neurology Neuroscience

·June 17, 2019·4 min read

Antioxidant puts up fight, but loses battle against protein linked to Alzheimer’s disease

During early Alzheimer's disease, SOD1 initially weakens levels of Tau protein. However, as the disease progresses, the antioxidant becomes less effective at protecting the brain against neurodegeneration.