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Scripps Research Institute

·March 29, 2021·4 min read

Experimental Antibodies for Parkinson’s and Alzheimer’s May Cause Harmful Inflammation

A new study reveals some experimental antibody treatments for neurodegenerative disorders increase neuroinflammation. The effect was seen in human microglia, not mouse microglia. This may explain why mouse studies have shown these treatments to be effective, but the effect has not been replicated in human studies.

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Featured Genetics Neurology Open Neuroscience Articles

·March 6, 2021·4 min read

Huntington’s Disease Driven by Slowed Protein-Building Machinery in Cells

The mutated huntingtin protein slows ribosome movement and decreases protein synthesis.

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Featured Neuroscience

·February 4, 2021·4 min read

Experimental Vaccine Blunts the Deadliest of Synthetic Opioids

A newly developed experimental vaccine can diminish the fatal respiratory effects of carfentanil and fentanyl in rodent models.

Featured Genetics Neurology Neuroscience

·February 3, 2021·5 min read

Unraveling the Mystery of Gao, a Protein Implicated in Movement Disorders

Study reveals the role the Gao protein plays in a rare genetic movement disorder often diagnosed during infancy and early childhood.

Featured Genetics Neurology Neuroscience

·December 6, 2020·5 min read

Hidden Network of Enzymes Accounts for Loss of Brain Synapses in Alzheimer’s

Researchers have identified a biochemical cascade that leads to the destruction of synapses in the brain. The findings open new avenues of research into the treatment of Alzheimer's disease.

Featured Genetics Neurology Open Neuroscience Articles

·September 16, 2020·4 min read

New Gene Implicated in ALS and Other Motor Neuron Diseases

A defective protein quality control system leads to motor neuron death associated with disorders like ALS.

Autism Featured Neuroscience Open Neuroscience Articles

·July 14, 2020·4 min read

Autism Researchers Map Brain Circuitry of Social Preference

Study reveals how two neural circuits dictate the choice between social approach and avoidance. The network connecting the infralimbic cortex to the basolateral amygdala (BLA) impairs social behavior if there is a decrease in neural activity. Another network connecting the prelimbic cortex to the BLA similarly impairs social behavior if the neural activity is increased.

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·June 12, 2020·3 min read

Up to 45 percent of COVID-19 infections may be asymptomatic

Study reveals up to 45% of people infected with COVID-19 were asymptomatic. The findings suggest asymptomatic infections likely played a significant role in the early and ongoing spread of coronavirus.

Featured Neurology Neuroscience Open Neuroscience Articles

·May 29, 2020·6 min read

Anesthesia’s effect on consciousness solved, settling century-old scientific debate

Exposure to anesthesia causes lipid clusters to move from an ordered state to a disordered one, then back again. These changes lead to subsequent effects that cause changes in consciousness.

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Featured Genetics Neurology Neuroscience

·May 1, 2020·5 min read

Parkinson’s dyskinesia mechanism explained

Involuntary movements and tremors caused as a result of taking dopamine replacement medications for Parkinson's disease can be alleviated through the suppression of RasGRP1.

Autism Featured Genetics Neuroscience Open Neuroscience Articles

·April 15, 2020·5 min read

Autism in males linked to defect in brain immune cells and microglia

An over-production of eIF4E impairs microglial cells, hampering their ability to effectively prune synapses and leading to autism-like behaviors in male mouse models of ASD.

Featured Neuroscience

·April 4, 2020·4 min read

Clues to COVID-19 coronavirus’s vulnerability emerge from an antibody against SARS

Structural mapping of both SARS and SARS-CoV-2, the virus that causes COVID-19, reveals an almost identical site on both coronaviruses to which the CR3022 antibody binds. This suggests a functionally important and vulnerable site for this family of coronaviruses.