Scripps Research Institute

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Scripps Research Institute

·March 29, 2021·4 min read

Experimental Antibodies for Parkinson’s and Alzheimer’s May Cause Harmful Inflammation

A new study reveals some experimental antibody treatments for neurodegenerative disorders increase neuroinflammation. The effect was seen in human microglia, not mouse microglia. This may explain why mouse studies have shown these treatments to be effective, but the effect has not been replicated in human studies.

Featured Neuroscience Open Neuroscience Articles

·March 18, 2019·5 min read

Scientists hunt down the brain circuit responsible for alcohol cravings

Optogenetic inactivation of CRF neurons in the central nucleus of the amygdala decreases escalation of alcohol consumption and intensity of withdrawal in rodent models of alcoholism. The findings suggest a potential target for treating excessive drinking in alcohol use disorder.

Featured Genetics Neurology Neuroscience

·September 30, 2019·4 min read

‘Relaxed’ enzymes may be at the root of Charcot-Marie-Tooth disease

The severity of Charcot-Marie-Tooth disease is linked to the degree to which the aminoacyl-tRNA synthetases enzyme is relaxed or extended.

Image shows the location of the amygdala in the brain.

Autism Featured Open Neuroscience Articles

·November 15, 2016·3 min read

Researchers Discover Clues to Altered Brain Wiring in Autism

Mutations in PTEN affect the assembly of connections between two brain areas important for the processing of social cues, researchers report.

Featured Neuroscience Open Neuroscience Articles

·June 8, 2022·5 min read

Immune Protein May Drive Alcoholism Relapse

An immune protein called CSF1 may contribute to feelings of anxiety as a result of alcohol withdrawal for those with alcohol use disorder.

Autism Featured Genetics Neuroscience Open Neuroscience Articles

·April 15, 2020·5 min read

Autism in males linked to defect in brain immune cells and microglia

An over-production of eIF4E impairs microglial cells, hampering their ability to effectively prune synapses and leading to autism-like behaviors in male mouse models of ASD.

This shows neurons. The caption best describes the image

Featured Genetics Neurology Open Neuroscience Articles

·March 6, 2021·4 min read

Huntington’s Disease Driven by Slowed Protein-Building Machinery in Cells

The mutated huntingtin protein slows ribosome movement and decreases protein synthesis.

Featured Neurology Neuroscience

·August 14, 2021·5 min read

Brain Cholesterol Regulates Alzheimer’s Plaques

A new advanced imaging technique shows how cholesterol regulates the production of Alzheimer's associated amyloid beta proteins in astrocytes.

Featured Genetics Neuroscience

·June 22, 2022·4 min read

Scientists Identify Sensor Underlying Mechanical Itch Stimulus

Study identifies a specific protein in sensory neurons that detects mechanical itch stimuli such as an insect crawling on the skin or when one touches an object that irritates the skin.

Featured Genetics Neuroscience

·April 16, 2021·3 min read

Neural Plasticity Depends On This Long Noncoding RNA’s Journey From Nucleus to Synapse

Study sheds new light on the role noncoded RNAs play at the synapse.

This shows proteins in the retinal cells

Featured Neuroscience

·January 31, 2022·4 min read

A New Type of Cellular Communication in the Brain

Researchers have identified hundreds of proteins that are consistently transported throughout the healthy brain via small membrane-enclosed sacs. The findings reveal a new form of communication between brain cells.

Featured Neurology Neuroscience

·February 1, 2022·4 min read

Compound in the Herb Rosemary May Be Useful Against COVID-19 and Other Inflammatory Diseases

Carnosic acid, a compound found in the herb rosemary, can block the interaction with the COVID-19 SARS_CoV_2 spike protein and ACE2, the protein receptor the virus uses to gain access into cells. The compound appears to have anti-inflammatory effects and has previously been associated with a reduction in Alzheimer's symptoms.

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