A new study reveals some experimental antibody treatments for neurodegenerative disorders increase neuroinflammation. The effect was seen in human microglia, not mouse microglia. This may explain why mouse studies have shown these treatments to be effective, but the effect has not been replicated in human studies.
Optogenetic inactivation of CRF neurons in the central nucleus of the amygdala decreases escalation of alcohol consumption and intensity of withdrawal in rodent models of alcoholism. The findings suggest a potential target for treating excessive drinking in alcohol use disorder.
Mutations in PTEN affect the assembly of connections between two brain areas important for the processing of social cues, researchers report.
An over-production of eIF4E impairs microglial cells, hampering their ability to effectively prune synapses and leading to autism-like behaviors in male mouse models of ASD.
Study identifies a specific protein in sensory neurons that detects mechanical itch stimuli such as an insect crawling on the skin or when one touches an object that irritates the skin.
Study sheds new light on the role noncoded RNAs play at the synapse.
Researchers have identified hundreds of proteins that are consistently transported throughout the healthy brain via small membrane-enclosed sacs. The findings reveal a new form of communication between brain cells.
Carnosic acid, a compound found in the herb rosemary, can block the interaction with the COVID-19 SARS_CoV_2 spike protein and ACE2, the protein receptor the virus uses to gain access into cells. The compound appears to have anti-inflammatory effects and has previously been associated with a reduction in Alzheimer's symptoms.