Researchers have discovered a two-pronged approach to restore myelin on regenerated axons in a mouse model of optic nerve damage. The findings have positive implications for the treatment of multiple sclerosis. Read More
N-acetylglucosamine, a simple sugar found in breast milk, promotes remyelination in mouse models of multiple sclerosis. The findings could have implications for treating multiple sclerosis in humans. Read More
eEF1a1 activated by acetylation prevents remyelination, but if the protein is deactivated by deacetylation, myelin sheaths can be rebuilt. The findings shed light on the process of remyelination and could provide avenues of treatment for multiple sclerosis, and other conditions associated with demyelination. Read More
Melanocyte stem cells from human hair follicles that carry CD34 have the ability to turn into glial cells. The CD34+ stem cells can regenerate myelin, both on neurons and in mouse models with a genetic defect that prevents the formation of healthy myelin sheaths. The findings could have positive implications for the treatment of demyelinating diseases, such as Multiple Sclerosis. Read More
A study in mouse models of multiple sclerosis demonstrates a compound called sobetirome promotes remyelination, and a derivative of the compound can penetrate the blood-brain barrier to enable a tenfold increase in infiltration to the CNS. Researchers are confident their research will translate from mice into humans, providing a new avenue of treatment for MS. Read More
Researchers discovered oligodendrocyte neurogenesis is limited in the brains of patients with Multiple Sclerosis. However, oligodendrocytes that survive the autoimmune attack associated with MS may be able to form new myelin. Read More
Study reveals PRRX1 gene expression results in cell cycle arrest and quiescence of oligodendrocyte progenitors, blocking myelin production. Read More
Researchers successfully used a synthetic compound to stimulate a receptor pathway to promote remyelination in the brain. The technique may have significant beneficial implications for treating multiple sclerosis, researchers say. Read More
A new study sheds light on demylination diseases like Multiple Sclerosis. Researchers discovered a blood clotting protein can leak into the central nervous system and prevent myelin production. Read More
Renewed, thin myelin sheaths are sufficient to help restore nervous system impairments in diseases like multiple sclerosis, a new study in PNAS reports. Read More
UCSF researchers reveal a common over the counter antihistamine appears to accelerate neural signaling and restore nervous system functioning for some multiple sclerosis patients. Read More
Researchers have been able to restore limb mobility and partially re-insulate neurons in mouse models of MS with microRNA treatments. Read More
