Researchers have discovered a two-pronged approach to restore myelin on regenerated axons in a mouse model of optic nerve damage. The findings have positive implications for the treatment of multiple sclerosis.
N-acetylglucosamine, a simple sugar found in breast milk, promotes remyelination in mouse models of multiple sclerosis. The findings could have implications for treating multiple sclerosis in humans.
eEF1a1 activated by acetylation prevents remyelination, but if the protein is deactivated by deacetylation, myelin sheaths can be rebuilt. The findings shed light on the process of remyelination and could provide avenues of treatment for multiple sclerosis, and other conditions associated with demyelination.
Melanocyte stem cells from human hair follicles that carry CD34 have the ability to turn into glial cells. The CD34+ stem cells can regenerate myelin, both on neurons and in mouse models with a genetic defect that prevents the formation of healthy myelin sheaths. The findings could have positive implications for the treatment of demyelinating diseases, such as Multiple Sclerosis.
A study in mouse models of multiple sclerosis demonstrates a compound called sobetirome promotes remyelination, and a derivative of the compound can penetrate the blood-brain barrier to enable a tenfold increase in infiltration to the CNS. Researchers are confident their research will translate from mice into humans, providing a new avenue of treatment for MS.
Researchers discovered oligodendrocyte neurogenesis is limited in the brains of patients with Multiple Sclerosis. However, oligodendrocytes that survive the autoimmune attack associated with MS may be able to form new myelin.
Researchers successfully used a synthetic compound to stimulate a receptor pathway to promote remyelination in the brain. The technique may have significant beneficial implications for treating multiple sclerosis, researchers say.
A new study sheds light on demylination diseases like Multiple Sclerosis. Researchers discovered a blood clotting protein can leak into the central nervous system and prevent myelin production.
Renewed, thin myelin sheaths are sufficient to help restore nervous system impairments in diseases like multiple sclerosis, a new study in PNAS reports.
UCSF researchers reveal a common over the counter antihistamine appears to accelerate neural signaling and restore nervous system functioning for some multiple sclerosis patients.
Researchers have been able to restore limb mobility and partially re-insulate neurons in mouse models of MS with microRNA treatments.