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psychopharmacology

·July 5, 2021·2 min read

Psychedelic Spurs Growth of Neural Connections Lost In Depression

One dose of psilocybin, the psychoactive compound found in magic mushrooms, increases dendritic spine density within 24 hours. The neurobiological changes lasted for a month following psilocybin exposure. Additionally, mice subjected to stress showed behavioral improvements and increased neurotransmitter activity after psilocybin exposure.

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·June 29, 2021·3 min read

Drug Relieves Persistent Daydreaming, Fatigue, and Brain Sluggishness in Adults With ADHD

Lisdexamfetamine, a drug known to stimulate brain activity, reduces symptoms of sluggish cognitive tempo in adults with ADHD.

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·June 28, 2021·4 min read

Novel Drug Reduces Anxiety-Like Behavior in Mice

KNT-127 reduced anxiety-like behaviors in mice, researchers report.

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·June 9, 2021·4 min read

Low Doses of “Laughing Gas” Could Be Fast, Effective Treatment for Severe Depression

Nitrous oxide, a common anesthesia most often associated with dental procedures, may have a new purpose. Researchers found a single inhalation of 25% nitrous oxide gas was effective at alleviating symptoms of depression in those with a treatment-resistant form of the mental health disorder.

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·June 4, 2021·5 min read

ADHD Drugs Can Affect Later Generations

A new study of male guppies reveals behaviors affected by methylphenidate hydrochloride (MPH), an active ingredient in common ADHD medications, can be passed along to future generations.

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·May 28, 2021·4 min read

Why Is It so Hard to Withdraw From Some Antidepressants?

A new study reveals the molecular and cellular mechanisms behind why some people find it harder to stop using antidepressants than others with depression.

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·May 25, 2021·4 min read

Non-Hallucinogenic Psychedelic Analog Reverses Effects of Stress in Mice

A single dose of tabernanthalog (TBG), a non-hallucinogenic psychedelic analog, corrects stress-induced behavioral deficits, including anxiety and cognitive inflexibility, in mouse models. Additionally, the compound promoted neurogenesis and restores neural circuits in brain areas damaged by stress.

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·May 19, 2021·6 min read

Commonly Used Drugs for Schizophrenia Linked to Greater Cognitive Impairment

Medications with anticholinergic properties given to help reduce physical and mental health symptoms associated with schizophrenia have a cumulative effect in reducing cognitive function in patients.

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·May 19, 2021·5 min read

Flies With Schizophrenia-Associated Genes Respond Well to Anti-Psychotics

Flies without the Rim gene or cac Cav2 channel function displayed numerous cognitive and behavioral deficits associated with schizophrenia, and had reductions in synaptic growth and neural calcium transients. Exposing the flies with Rim deficits to the common antipsychotic haloperidol reduced some of the schizophrenia-related behavioral symptoms.

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·May 3, 2021·4 min read

Same Drug Can Have Opposite Effects on Memory Depending on Sex

Osanetant, a drug that inhibits the Tac2 pathway, has opposite effects on the recall of traumatic events in male and female mice.

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·April 28, 2021·4 min read

A Psychedelic-Like Drug Without the Hallucinogenic Side Effects

PsychLight, a newly developed genetically encoded fluorescent sensor, helped researchers identify a psychedelic compound that acts on beneficial neural pathways to treat psychiatric disorders without the hallucinogenic effect.

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·April 13, 2021·4 min read

Psychedelic Experience May Not Be Required For Psilocybin’s Antidepressant-Like Benefits

A mouse study refutes the common belief that psilocybin's ability to produce an anti-depressant effect is attributed to the psychedelic experience it creates. Blocking the psychedelic effect did not affect psilocybin's anti-depressant effects.