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psychopharmacology

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·May 25, 2021·4 min read

Non-Hallucinogenic Psychedelic Analog Reverses Effects of Stress in Mice

A single dose of tabernanthalog (TBG), a non-hallucinogenic psychedelic analog, corrects stress-induced behavioral deficits, including anxiety and cognitive inflexibility, in mouse models. Additionally, the compound promoted neurogenesis and restores neural circuits in brain areas damaged by stress.

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·May 19, 2021·6 min read

Commonly Used Drugs for Schizophrenia Linked to Greater Cognitive Impairment

Medications with anticholinergic properties given to help reduce physical and mental health symptoms associated with schizophrenia have a cumulative effect in reducing cognitive function in patients.

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·May 19, 2021·5 min read

Flies With Schizophrenia-Associated Genes Respond Well to Anti-Psychotics

Flies without the Rim gene or cac Cav2 channel function displayed numerous cognitive and behavioral deficits associated with schizophrenia, and had reductions in synaptic growth and neural calcium transients. Exposing the flies with Rim deficits to the common antipsychotic haloperidol reduced some of the schizophrenia-related behavioral symptoms.

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·May 3, 2021·4 min read

Same Drug Can Have Opposite Effects on Memory Depending on Sex

Osanetant, a drug that inhibits the Tac2 pathway, has opposite effects on the recall of traumatic events in male and female mice.

Featured Neuroscience Psychology

·April 28, 2021·4 min read

A Psychedelic-Like Drug Without the Hallucinogenic Side Effects

PsychLight, a newly developed genetically encoded fluorescent sensor, helped researchers identify a psychedelic compound that acts on beneficial neural pathways to treat psychiatric disorders without the hallucinogenic effect.

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Featured Neuroscience Psychology

·April 13, 2021·4 min read

Psychedelic Experience May Not Be Required For Psilocybin’s Antidepressant-Like Benefits

A mouse study refutes the common belief that psilocybin's ability to produce an anti-depressant effect is attributed to the psychedelic experience it creates. Blocking the psychedelic effect did not affect psilocybin's anti-depressant effects.

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Featured Neuroscience Psychology

·April 6, 2021·4 min read

Resurging Psychedelic Therapies for Depression

As interest in using psychedelics to treat a range of mental health disorders grows, researchers consider the impact and therapeutic benefits of using psychedelics to help alleviate symptoms of depression.

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Featured Neuroscience Psychology

·March 3, 2021·6 min read

Researchers Identify Brain Ion Channel as New Approach to Treating Depression

Ezogabine, a drug that opens up the KCNQ2/3 type potassium channel, significantly improved symptoms of depression and anhedonia.

Featured Neuroscience Psychology

·February 21, 2021·4 min read

From Trippy Drugs to Therapeutic Aids – How Psychedelics Got Their Groove Back

From microdosing to improve cognition, to treating a range of mental health disorders, researchers evaluate the rise in the use of psychedelics and their potential as medicines.

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Featured Neuroscience Psychology

·February 18, 2021·4 min read

New Information on the Effects of Antidepressants

SSRI's, ketamine, and tricyclic antidepressants all bind with TrkB. The findings challenge the roles serotonin and glutamate receptors play in the effects of antidepressant medications.

Featured Genetics Neuroscience Open Neuroscience Articles Psychology

·January 30, 2021·4 min read

Why Do Psychiatric Drugs Help Some, but Not Others?

Study reveals the function of a specific protein works differently in the brains of men and women. The findings help explain why some psychiatric disorders and resistance to treatments vary between the sexes.

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·January 26, 2021·5 min read

LSD May Offer Viable Treatment for Certain Mental Disorders

LSD increases social behaviors by activating 5-HTPA serotonin receptors and AMPA receptors in the prefrontal cortex, and the mTORC1 protein. Activating all three factors promoted social interactions. The findings suggest supervised LSD microdosing may help alleviate some of the social problems associated with ASD and other mental health disorders that impact social behaviors.