The loss of the protein neurofibromin 1 (NF1) in adult male flies resulted in social impairments. The deficits were traced back to a primary disruption in a small group of peripheral neurons which control external stimuli, including touch and smell, that communicate to the brain. Read More
Neurons and immune cells work together to promote tumor growth in neurofibromatosis type 1. Read More
Immune cells can accelerate the growth of cancerous tumors in mouse models of NF1. Read More
CRISPR technology and advanced screening techniques allow researchers to comb through over 1500 genetic combinations to find multiple drivers of glioblastoma brain cancer. Read More
A new study suggests blocking estrogen may help preserve eyesight in girls with NF1. Read More
Researchers believe their findings could lead to new targets for brain cancer therapies. Read More
A new study reveals that a single gene may be linked to some cases of ASD. Read More
Researchers report the learning and memory deficits associated with neurofibromatosis are distinct features which require different treatment approaches. Read More
Scientists have long believed that glioblastoma multiforme, the most aggressive type of primary brain tumor, begins in glial cells that make up supportive tissue in the brain or in neural stem cells. Researchers found that the tumors can originate from other types of differentiated cells in the nervous system, including cortical neurons. Read More
U-M scientists stop abnormal brain cell growth in mice with neurofibromatosis using experimental tumor drug, make new discoveries in neural stem cells. Read More
Scientists showed in mice that disabling a gene linked to a common pediatric tumor disorder, neurofibromatosis type 1 (NF1), made stem cells from one part of the brain proliferate rapidly. But the same genetic deficit had no effect on stem cells from another brain region. Read More
Southwestern Medical Center investigators have identified a genetic manipulation that increases the development of neurons in the brain during aging... Read More