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neuropsychopharmacology

·January 15, 2023·5 min read

Old Antipsychotic Drugs May Offer New Option to Treat Type 2 Diabetes

Diphenylbutylpiperidines (DPBPs), an older class of antipsychotic medications can effectively be repurposed to help treat type 2 diabetes, a new study reports.

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·January 6, 2023·7 min read

Blood Pressure Drug Holds Promise for Treating PTSD

Clonidine, an FDA-approved medication commonly prescribed to treat blood-pressure disorders and ADHD, shows promise in mitigating the effects of PTSD.

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·December 30, 2022·4 min read

Ketamine Found to Increase Brain Noise

By inhibiting NMDA receptors, ketamine increases noise to gamma frequencies in one layer of the thalamic nucleus and one lay of the somatosensory cortex. Findings suggest psychosis may be triggered by an increase in background noise impairing thalamocortical neurons which may be caused by a malfunction in NMDA receptors affecting the balance of inhibition and excitation in the brain.

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·December 9, 2022·4 min read

A Better Understanding of How the Most Commonly Used ADHD Medication Works

Study reveals how methylphenidate interacts with cognitive control networks and attention behaviors. Methylphenidate changes spontaneous neural activity in reward and cognitive control systems in children with ADHD. The changes result in more stable sustained attention.

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·December 2, 2022·4 min read

How Ketamine Acts as a ‘Switch’ in the Brain

Ketamine alters neural activity in the cerebral cortex, silencing normally active neurons and activating neurons that are normally inactive. The ketamine activity-induced "switch" in brain regions associated with depression may help explain its treatment effects.

This shows Vyvanse (Lisdexamfetamine) 70mg capsules

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·November 17, 2022·5 min read

ADHD Medication for Amphetamine Addiction Linked to Reduced Risk of Hospitalization and Death

Lisdexamfetamine (Vyvanse), a medication commonly used to treat ADHD, lowers the risk of hospitalization and death for those with amphetamine use disorder.

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·May 20, 2022·3 min read

Novel Preclinical Drug Could Have Potential to Combat Depression, Brain Injury, and Cognitive Disorders

A preclinical drug that inhibits the kinase enzyme Cdk5 may have the potential to treat depression, brain injuries, and disorders associated with cognitive impairment.

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·May 14, 2022·6 min read

Six Lithium Dose Predictors for Patients With Bipolar Disorder

Researchers have identified six predictors that may help determine the correct amount of lithium to treat a patient with bipolar disorder.

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·April 23, 2022·4 min read

Fetal Exposure to Antidepressants May Affect Infants’ Brain Development

Fetal exposure to antidepressants or antiepileptic medications may affect the development of newborn brain networks.

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·April 14, 2022·5 min read

A Drug That Cures Alcoholism May Be the Next Anti-anxiety Medication

Disulfiram, a drug commonly prescribed to treat chronic alcohol addiction, was shown to reduce anxiety levels in rodent models. The drug inhibits FROUNT protein and chemokine signaling pathways under its influence, suppressing overall glutamate transmission in the brain. This, in turn, helps reduce overall activity. The findings may signal a new way to treat anxiety in humans.