neuropsychopharmacology

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neuropsychopharmacology

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·December 2, 2022·4 min read

How Ketamine Acts as ‘Switch’ in the Brain

Ketamine alters neural activity in the cerebral cortex, silencing normally active neurons and activating neurons that are normally inactive. The ketamine activity-induced "switch" in brain regions associated with depression may help explain its treatment effects.

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·November 17, 2022·5 min read

ADHD Medication for Amphetamine Addiction Linked to Reduced Risk of Hospitalization and Death

Lisdexamfetamine (Vyvanse), a medication commonly used to treat ADHD, lowers the risk of hospitalization and death for those with amphetamine use disorder.

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·May 20, 2022·3 min read

Novel Preclinical Drug Could Have Potential to Combat Depression, Brain Injury, and Cognitive Disorders

A preclinical drug that inhibits the kinase enzyme Cdk5 may have the potential to treat depression, brain injuries, and disorders associated with cognitive impairment.

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·May 14, 2022·6 min read

Six Lithium Dose Predictors for Patients With Bipolar Disorder

Researchers have identified six predictors that may help determine the correct amount of lithium to treat a patient with bipolar disorder.

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·April 23, 2022·4 min read

Fetal Exposure to Antidepressants May Affect Infants’ Brain Development

Fetal exposure to antidepressants or antiepileptic medications may affect the development of newborn brain networks.

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·April 14, 2022·5 min read

A Drug That Cures Alcoholism May Be the Next Anti-anxiety Medication

Disulfiram, a drug commonly prescribed to treat chronic alcohol addiction, was shown to reduce anxiety levels in rodent models. The drug inhibits FROUNT protein and chemokine signaling pathways under its influence, suppressing overall glutamate transmission in the brain. This, in turn, helps reduce overall activity. The findings may signal a new way to treat anxiety in humans.

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·March 18, 2022·4 min read

Researchers Explore Therapeutic Uses of Ketamine

Researchers report ketamine may have a broader use for the treatment of psychological disorders beyond a treatment for depression and anxiety.

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·March 16, 2022·3 min read

Largest Ever Psychedelics Study Maps Changes of Conscious Awareness to Neurotransmitter Systems

Study reveals how psychedelic drug-induced changes in subjective awareness are rooted in specific neurotransmitter systems.

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·March 6, 2022·2 min read

How Long-Term Benzodiazepine Use Leads to Cognitive Impairments

Mouse study reveals synaptic loss associated with a daily sleep-inducing dose of diazepam for several weeks leads to cognitive impairments. However, the effect was reversible after discontinuing benzodiazepine use.

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·November 19, 2021·5 min read

Psychedelics Show Promise in Treating Mental Illness

A growing body of evidence suggests psychedelics including psilocybin and LSD show promise in providing lasting relief from symptoms for those suffering some mental health disorders. Researchers found DOI, a similar drug to LSD, reduced negative behavioral responses following fear triggers in mouse models of anxiety.

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·October 22, 2021·4 min read

Common Antidepressant Should No Longer Be Used to Treat People With Dementia

Mirtazapine, an antidepressant commonly prescribed to treat dementia-associated agitation, is no more effective than a placebo and may increase mortality risks, researchers report.

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·October 14, 2021·4 min read

Brain Activity Fluctuations May Hold the Keys to Psychiatric Treatment Efficacy

Moment-to-moment fluctuations in brain activity over a three-minute period can reliably predict how receptive a person with social anxiety will be to cognitive behavioral therapy.

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