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neuropsychopharmacology

This shows the outline of a head in psychedelic colors.

·November 24, 2025·4 min read

Psychedelic ‘Ego Death’ Tied to a Collapse in Alpha Brain Waves

A new study using DMT as a scientific tool reveals how psychedelics alter the brain’s alpha-wave dynamics and weaken our sense of self. The researchers found that DMT pushes the brain away from its usual “critical” balance between chaos and order, a state believed to be essential for coherent self-awareness over time.

This shows a man holding a wine glass against a psychedelic backdrop.

Featured Neuroscience

·November 10, 2025·4 min read

Psychedelics Calm Stress Circuits to Reduce Alcohol Drinking

New research shows that psilocin, the active metabolite of the psychedelic psilocybin, may reduce alcohol consumption by calming stress-sensitive neurons in the central amygdala. In female mice exposed to long-term alcohol use, psilocin dampened the hyperactivity of these neurons, temporarily reducing drinking.

Featured Neuroscience Psychology

·October 27, 2025·4 min read

Psychedelics May Rewire Memory Circuits Key to Mental Health

New research suggests that psychedelic drugs may work by strengthening specific brain connections linked to memory and cognition. Scientists found that under psychedelic exposure, neurons in the claustrum—a region dense with psychedelic-sensitive receptors—intensified their communication with the anterior cingulate cortex, a region involved in mood and psychiatric disorders.

Featured Neurology Neuroscience

·September 17, 2025·4 min read

Psychedelics Show Promise for Healing Concussions and Brain Injuries

Traumatic brain injuries, including concussions, affect nearly 69 million people worldwide each year, yet treatments remain scarce. A new review highlights the potential of psychedelics such as psilocybin and 5-MeO-DMT to reduce harmful inflammation and enhance neuroplasticity after brain injury.

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·June 3, 2025·7 min read

Ibudilast Fails to Beat Placebo in Alcoholism Trial, Except in Women

A recent clinical trial found that ibudilast, a drug once promising for alcohol use disorder, was no more effective than a placebo overall. While all participants reduced their drinking, women on ibudilast showed a greater drop in drinks per day, hinting at a gender-specific benefit.

Featured Neurology Neuroscience

·May 30, 2025·4 min read

SSRIs Restore Brain Function in Alzheimer’s

A new study suggests that SSRIs, commonly prescribed antidepressants, may reduce biological markers of Alzheimer’s disease. In a cohort of 191 individuals, AD patients on SSRIs had lower levels of plasma phosphorylated tau-181, a key indicator of disease severity.

Featured Neuroscience Psychology

·February 14, 2025·6 min read

Prozac Shows Promise in Fighting Infections & Sepsis

New research suggests that fluoxetine, commonly used as an antidepressant, may also help protect against infections and sepsis. Scientists found that the drug has antimicrobial properties and helps regulate the immune response, reducing the risk of tissue and organ damage.

Featured Neurology Neuroscience Psychology

·April 20, 2024·7 min read

Risks of Antipsychotic Use in Dementia Patients

A new study revealed significant risks associated with antipsychotic use in dementia patients, including increased chances of stroke, heart failure, pneumonia, and other serious conditions. The research analyzed data from 173,910 dementia patients in England, tracking those prescribed antipsychotics post-diagnosis against those who were not.

This shows a pink brain and a blue brain.

Featured Neuroscience Psychology

·February 12, 2024·7 min read

Ketamine’s Effects Diverge by Sex

Ketamine's effects on depression and pain, and its interaction with opioid pathways, significantly differ between sexes. In a detailed rat study, the team found that blocking opioid receptors nullified ketamine's impact only in males, suggesting a complex interplay between ketamine, opioid systems, and sex hormones.

Featured Neuroscience Psychology

·February 21, 2023·5 min read

Medication Targeting Brain Stress Response May Help Cardiovascular Symptoms of Alcohol Withdrawal

Prazosin, an FDA-approved medication for the treatment of hypertension may help to prevent relapse in people with cardiovascular and behavioral symptoms of alcohol withdrawal, a new study reports.

Featured Neuroscience Psychology

·February 16, 2023·3 min read

Receptor Location Matters for Psychedelic Drug Effects

Location bias may explain how psychedelic medications work. Researchers found that engaging serotonin 2A receptors inside neurons promotes the growth of new connections, but engaging the same receptor on the outside of a neuron does not. The findings may guide the development of new psychoplastogens to treat a range of disorders including depression and PTSD.

Autism Featured Neuroscience Open Neuroscience Articles

·February 14, 2023·4 min read

Drug Shown to Alleviate Autism-Associated Behavior

A newly developed drug that blocks sodium channels in the cell membrane that can reverse MYT1L failure alleviates social behavior deficits in mouse models of ASD.