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neurodegeneration

·April 30, 2025·5 min read

Skin Test Detects Neurodegenerative Disease PSP with High Accuracy

Researchers have developed a skin-based test that can detect misfolded tau proteins specific to progressive supranuclear palsy (PSP), offering a faster, more accurate diagnosis than current methods. This breakthrough could improve patient assignment to clinical trials and eventually guide targeted, precision treatments.

Featured Neuroscience

·January 21, 2025·5 min read

Microglia Act Differently in Male and Female Brains

Microglia, the brain’s immune cells, play vital roles in clearing toxins and maintaining neuronal health but can also contribute to neurodegenerative diseases if overactive. New research reveals sex-based differences in how adult male and female microglia respond to the enzyme inhibitor PLX3397, a common tool in microglial research. While male microglia showed the expected depletion, female microglia employed alternative signaling pathways, leading to increased survival.

Featured Neuroscience

·October 22, 2024·3 min read

“Zombie” Aging Cells May Speed Up Brain Decline

Recent research shows that senescent, or "zombie," skin cells may accelerate aging throughout the body. When transplanted into a preclinical model, these cells caused senescence to spread to other organs, impairing muscle function and brain health.

Featured Genetics Neurology Neuroscience

·October 1, 2024·3 min read

New Genetic Syndrome Links Brain Development and Degeneration

Researchers have discovered a new genetic syndrome caused by a mutation in the SPAG9 gene that affects both neurodevelopment and neurodegeneration. The study identified three siblings with intellectual disability, speech delays, and progressive cognitive decline, linking the mutation to disruptions in brain structure and function. Neuroimaging revealed abnormalities such as microcephaly, hippocampal malrotation, and cerebral atrophy.

Featured Neurology Neuroscience

·August 16, 2024·5 min read

Restoring Brain’s Waste-Clearing System Reverses Aging Effects

New research in mice reveals that aging slows the brain's ability to clear out harmful waste, contributing to neurological disorders like Alzheimer's and Parkinson's. Scientists have found that restoring function in the brain's waste-clearing system, known as the glymphatic system, can reverse these age-related effects. Using a clinically approved drug, researchers increased the efficiency of waste removal, offering a potential treatment strategy for age-related brain diseases.

Featured Neurology Neuroscience

·April 8, 2024·4 min read

Revolutionizing Neuron Observation for Disease Insight

A new neuron labeling technology, NeuM, has been developed, offering unprecedented insights into the mechanisms of neurodegenerative disorders like Alzheimer's and Parkinson's disease. NeuM enables selective, high-resolution visualization of neuronal membranes, allowing for the detailed monitoring of neuronal changes in real-time.

Featured Genetics Neurology Neuroscience

·April 4, 2024·5 min read

Brain Organoids Illuminate TBI’s Link to Neurodegeneration

Researchers have advanced our understanding of how traumatic brain injuries (TBI) contribute to neurodegenerative diseases using lab-grown brain organoids. By simulating TBI in organoids derived from human stem cells, the team observed nerve cell death and pathological changes similar to those in TBI patients, particularly in proteins associated with ALS and dementia.

Autism Featured Genetics Neurology Neuroscience

·April 4, 2024·4 min read

Genetic Link Between Left-Handedness and Neurological Disorders

A new study utilizing UK Biobank data has unveiled the genetic roots of left-handedness, pinpointing rare variants in the beta-tubulin gene TUBB4B significantly associated with this trait. These findings not only shed light on the complex interplay between genetics and brain asymmetry but also link left-handedness with neurodevelopmental disorders through shared genetic pathways.

Featured Neurology Neuroscience

·March 5, 2024·4 min read

AI Reveals Brain Oscillations for Memory and Disease

A recent study showcases a significant leap in the study of brain oscillations, particularly ripples, which are crucial for memory organization and are affected in disorders like epilepsy and Alzheimer's. Researchers have developed a toolbox of AI models trained on rodent EEG data to automate and enhance the detection of these oscillations, proving their efficacy on data from non-human primates.

Featured Genetics Neurology Neuroscience

·January 8, 2024·5 min read

Novel Gene Linked to Range of Neurodegenerative Diseases Identified

Researchers uncovered a crucial link between the gene Angiogenin (ANG) and age-related neurodegenerative diseases such as frontotemporal dementia (FTD), motor neuron disease (MND), and Parkinson's disease. In its mutated form, ANG causes stem cells to delay their differentiation into specialized nerve cells, leading to neurodevelopmental defects.

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Featured Neurology Neuroscience

·November 7, 2023·4 min read

High-Sugar Diets May Fuel Brain Decline

Research suggests a high-sugar diet, commonly associated with obesity, leads to insulin resistance in the brain and may heighten the risk of neurodegenerative diseases like Alzheimer's. The study reveals that this insulin resistance impairs glial cells' ability to clear neuronal debris, a crucial process for preventing neurodegeneration.

Featured Neuroscience

·September 19, 2023·5 min read

Aging in the Brain: Microglial Changes Differ Between Sexes

Researchers delved into how microglial cells in the brain age and their link to brain dysfunction. Their study, using male and female mice, found surprising sex-based distinctions in microglial aging.

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neurodegeneration

Skin Test Detects Neurodegenerative Disease PSP with High Accuracy

Microglia Act Differently in Male and Female Brains

“Zombie” Aging Cells May Speed Up Brain Decline

New Genetic Syndrome Links Brain Development and Degeneration

Restoring Brain’s Waste-Clearing System Reverses Aging Effects

Revolutionizing Neuron Observation for Disease Insight

Brain Organoids Illuminate TBI’s Link to Neurodegeneration

Genetic Link Between Left-Handedness and Neurological Disorders

AI Reveals Brain Oscillations for Memory and Disease

Novel Gene Linked to Range of Neurodegenerative Diseases Identified

High-Sugar Diets May Fuel Brain Decline

Aging in the Brain: Microglial Changes Differ Between Sexes

Vitamin D May Slow Biological Aging

AI-Guided Gene Vectors Precisely Target Brain and Spinal Cells

Long COVID Is Fueling a Mental Health Crisis in Children

How the Brain Stores and Edits Memories

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