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Mount Sinai Hospital

·December 8, 2025·5 min read

PTSD Linked to Accelerated Brain Aging

A new study using advanced deep-learning brain age estimation shows that World Trade Center responders with PTSD exhibit signs of accelerated brain aging. Using BrainAgeNeXt, a model trained on more than 11,000 MRI scans, researchers found that responders with PTSD had “older” appearing brains than those without the disorder, especially among individuals with longer exposure at Ground Zero.

This shows a pregnant woman and a brain surrounded by pills.

Autism Featured Neuroscience

·August 18, 2025·5 min read

Prenatal Acetaminophen Linked to Higher Autism, ADHD Risk

A new study has raised concerns about the safety of acetaminophen use during pregnancy, linking prenatal exposure to higher risks of autism and ADHD. Using the gold-standard Navigation Guide review method, the team analyzed 46 studies with over 100,000 participants, finding that stronger studies more consistently showed a connection.

This shows a brain with the striatum highlighted.

Featured Neuroscience Psychology

·August 14, 2025·5 min read

Brain Circuit Model Reveals How Striatum Shapes Everyday Decisions

Researchers have developed a computational framework that maps how the striosomal compartment of the striatum governs everyday decision-making. By integrating biology, decision theory, and mathematical modeling, the study reveals that different levels of striosomal activity can push individuals toward impulsive, balanced, or overly complex decisions.

This is a visual representation of the 5-HT1A serotonin receptor.

Featured Neuroscience Psychology

·August 2, 2025·6 min read

Fat Molecule May Control How You Feel Emotion

Scientists have uncovered how the brain’s 5-HT1A serotonin receptor—vital in mood regulation—functions at the molecular level. This receptor, a common target of antidepressants and psychedelics, prefers certain signaling pathways no matter the drug, but drugs can still vary in how strongly they activate them.

Featured Neuroscience

·June 19, 2025·5 min read

Gut Bacteria, Food Insecurity, and Cognitive Risk Intertwined

A new study highlights how food insecurity may intensify the relationship between gut microbiome imbalances and cognitive impairment in adults. Analyzing data from 360 participants, researchers found specific bacterial “cliques” linked to poor cognitive outcomes, especially among those with limited access to nutritious food.

This shows sister moms and their babies.

Featured Genetics Neuroscience Psychology

·May 21, 2025·5 min read

Postpartum Psychosis May Run in Families

Women are over 10 times more likely to develop postpartum psychosis if their sister has experienced the condition, according to a major study of more than 1.6 million women. This rare but severe disorder, marked by hallucinations, paranoia, and disorganized thinking after childbirth, can have life-threatening consequences if not treated.

Featured Neuroscience Psychology

·May 7, 2025·5 min read

Dopamine’s Hidden Role in Anxiety Revealed

Dopamine receptors in the ventral hippocampus play a critical role in balancing approach and avoidance behaviors, expanding understanding beyond dopamine’s known functions in reward and motivation. By studying D1 and D2 receptor-expressing neurons in mice, researchers found these receptors govern opposing emotional responses under stress.

Featured Neuroscience

·April 30, 2025·4 min read

How the Brain Judges Social Encounters

Scientists have identified the neural circuitry responsible for assigning emotional value—positive or negative—to social encounters. Two key neuromodulators, serotonin and neurotensin, were found to control opposing emotional responses in a brain region responsible for learning and memory.

Featured Genetics Neuroscience

·April 12, 2025·4 min read

Newly Discovered Gene Mutation Linked to Neurodevelopmental Disorders

Researchers have identified mutations in the non-coding gene RNU2-2 as a cause of a newly defined neurodevelopmental disorder, often accompanied by severe epilepsy. The discovery sheds light on the critical role of small non-coding genes in brain development and could affect thousands of families globally.

Featured Genetics Neuroscience

·February 18, 2025·5 min read

Nanoparticles Deliver mRNA to the Brain, Bypassing Blood-Brain Barrier

Scientists have developed a lipid nanoparticle system that enables mRNA to cross the blood-brain barrier, a long-standing challenge in neuroscience. In studies using mice and human brain tissue, these nanoparticles successfully delivered therapeutic mRNA, opening doors for potential treatments for neurological diseases like Alzheimer’s, ALS, and brain cancer.

Featured Genetics Neurology Neuroscience

·November 25, 2024·4 min read

New Platform Overcomes Blood-Brain Barrier for Drug Delivery

Researchers have developed a breakthrough system to deliver large therapeutic molecules into the brain, overcoming the challenges of the blood-brain barrier.

Featured Neuroscience

·November 7, 2024·5 min read

How the Brain Links Old and New Memories for Adaptive Learning

Researchers have revealed a neural mechanism in the brain that enables memories to integrate across different times and experiences. This study, conducted in mice, shows that memories are replayed and reactivated not only after significant events but also in ways that connect them with previous, related experiences. The findings highlight how memories are dynamically updated, supporting both adaptive processes like learning and potentially maladaptive ones like PTSD.