Reducing H3Q5dop in rat models of cocaine withdrawal significantly reversed cocaine mediated gene expression changes and reduced cocaine-seeking behaviors.
In the largest genetic sequencing study of autism conducted to date, researchers have identified 102 genes associated with the neurodevelopmental disorder. 49 of the genes were also associated with other developmental delays. The new study has enabled the researchers to increase the number of ASD associated genes from 65 to 102.
Long term outcome data of patients with treatment-resistant depression found subcallosal cingulate deep brain stimulation (SCC DBS) was both effective at relieving symptoms and safe.
People with schizophrenia who experience auditory hallucinations have greater activation in specific areas of the auditory cortex in response to sound frequencies. The mapping of sound frequency in the auditory cortex is scrambled in those with schizophrenia, suggesting a disruption in the normal processes for organized sound representation in the brain. As the tonotopic map is established during infancy and remains stable throughout life, the findings suggest vulnerability for auditory hallucinations is linked to defects in the organization of the auditory system during infantile development. This precedes speech development and the onset of psychiatric symptoms.
CBD reduces craving and anxiety in those with heroin use disorder during withdrawal from the drug. There were no serious adverse reactions, or impairments to cognition noted with the administration of CBD. Researchers suggest cannabidiol may be useful in helping to combat opioid addiction.
A study of more than 50,000 patients with bipolar disorder in 14 countries helped researchers identify 20 new genetic risk factors for bipolar disorder. Eight of the genes also had an association with an increased risk for schizophrenia. ASD and anorexia, it was discovered, also had genetic ties to bipolar depression.
A new study reports herpes virus utilizes ancient RNA to proliferate, mimicking the same process tumors have been found to manipulate. The findings could have implications for new treatment options and also may shed light on neurodegenerative diseases.
Ezogabine, an FDA approved anti-convulsant, appears to significantly reduce symptoms in those with major depressive disorder.