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Mount Sinai Hospital

·April 12, 2025·4 min read

Newly Discovered Gene Mutation Linked to Neurodevelopmental Disorders

Researchers have identified mutations in the non-coding gene RNU2-2 as a cause of a newly defined neurodevelopmental disorder, often accompanied by severe epilepsy. The discovery sheds light on the critical role of small non-coding genes in brain development and could affect thousands of families globally.

Featured Genetics Neuroscience

·February 18, 2025·5 min read

Nanoparticles Deliver mRNA to the Brain, Bypassing Blood-Brain Barrier

Scientists have developed a lipid nanoparticle system that enables mRNA to cross the blood-brain barrier, a long-standing challenge in neuroscience. In studies using mice and human brain tissue, these nanoparticles successfully delivered therapeutic mRNA, opening doors for potential treatments for neurological diseases like Alzheimer’s, ALS, and brain cancer.

Featured Genetics Neurology Neuroscience

·November 25, 2024·4 min read

New Platform Overcomes Blood-Brain Barrier for Drug Delivery

Researchers have developed a breakthrough system to deliver large therapeutic molecules into the brain, overcoming the challenges of the blood-brain barrier.

Featured Neuroscience

·November 7, 2024·5 min read

How the Brain Links Old and New Memories for Adaptive Learning

Researchers have revealed a neural mechanism in the brain that enables memories to integrate across different times and experiences. This study, conducted in mice, shows that memories are replayed and reactivated not only after significant events but also in ways that connect them with previous, related experiences. The findings highlight how memories are dynamically updated, supporting both adaptive processes like learning and potentially maladaptive ones like PTSD.

Featured Genetics Neuroscience Psychology

·October 11, 2024·4 min read

New Genetic Mutations Linked to Schizophrenia Risk

A study has identified mutations arising during brain development that may contribute to schizophrenia. Unlike inherited genes, these somatic mutations occur after conception and were found more frequently in schizophrenia patients' brain tissue. By sequencing DNA from neurons in the dorsolateral prefrontal cortex, researchers identified single-nucleotide variants linked to disrupted brain functions. This discovery highlights the importance of studying both inherited and non-inherited genetic factors.

Featured Neurology Neuroscience

·May 27, 2024·4 min read

New Alzheimer’s Breakthrough Targets Plexin-B1 Protein

Researchers identified a novel way to potentially slow or halt Alzheimer's progression by targeting the plexin-B1 protein. Their study shows how reactive astrocytes and plexin-B1 play crucial roles in clearing amyloid plaques. This discovery opens new pathways for Alzheimer's treatments and emphasizes the importance of cellular interactions.

Featured Neuroscience Psychology

·May 8, 2024·5 min read

Psychedelics Activate Serotonin to Produce Antidepressant Effect

A new study advanced our understanding of how psychedelic drugs activate serotonin receptors to offer potential treatments for neuropsychiatric disorders. The identifies the interaction of psychedelics like LSD and psilocybin with the serotonin receptor 5-HT1A, which is pivotal in their therapeutic effects.

Featured Genetics Neuroscience Psychology

·April 18, 2024·8 min read

How Drugs Hijack the Brain’s Reward System

Researchers made significant advances in understanding how drugs like cocaine and morphine disrupt the brain's natural reward mechanisms. Their study reveals that these drugs manipulate the same brain cells responsible for processing natural rewards, leading to compulsive drug-seeking behaviors.

This shows a person looking at brain scans.

Featured Neurology Neuroscience

·March 25, 2024·4 min read

Mapping Brain Activity with Brain-Computer Interface Technology

Researchers are trialing a novel brain-computer interface (BCI) with the potential to transform neurosurgical procedures and patient care. The Layer 7 Cortical Interface, boasting 1,024 electrodes for unparalleled brain activity mapping, promises new insights into neurological and psychiatric conditions.

Featured Neuroscience Psychology

·November 30, 2023·4 min read

Brain Activity in PTSD: Trauma Memories Differ from Sad Ones

A new study reveals distinct differences in brain activity between traumatic memories in PTSD patients and regular sad autobiographical memories. This research, the first of its kind to examine real-life personal memories, found that traumatic memories do not activate typical memory-related brain regions like the hippocampus, suggesting they're not processed as regular memories.

Featured Neuroscience

·November 22, 2023·7 min read

Brain Pathway Discovery Offers Hope in Addiction Treatment

Researchers made a pivotal discovery in addiction science, identifying a signaling impairment in the brain pathway of individuals dependent on cocaine or heroin. They used diffusion MRI tractography to examine the prefrontal cortex-habenula pathway, revealing microstructural disruptions in people with cocaine or heroin addiction.

Featured Neurology Neuroscience

·October 31, 2023·8 min read

Brain Impacts of Intimate Partner Violence

Researchers, in a comprehensive brain autopsy study, discovered significant vascular and white matter damage in women who experienced intimate partner violence. Unlike in male contact sports athletes, no evidence of CTE was detected.

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Mount Sinai Hospital

Newly Discovered Gene Mutation Linked to Neurodevelopmental Disorders

Nanoparticles Deliver mRNA to the Brain, Bypassing Blood-Brain Barrier

New Platform Overcomes Blood-Brain Barrier for Drug Delivery

How the Brain Links Old and New Memories for Adaptive Learning

New Genetic Mutations Linked to Schizophrenia Risk

New Alzheimer’s Breakthrough Targets Plexin-B1 Protein

Psychedelics Activate Serotonin to Produce Antidepressant Effect

How Drugs Hijack the Brain’s Reward System

Mapping Brain Activity with Brain-Computer Interface Technology

Brain Activity in PTSD: Trauma Memories Differ from Sad Ones

Brain Pathway Discovery Offers Hope in Addiction Treatment

Brain Impacts of Intimate Partner Violence

How Severe Illness During Pregnancy Alters Fetal Brain Development

Aging Brains Maintain Robust Language Networks Despite Cognitive Decline

Youth Protein TIMP2 Restores Immune Function in the Aging Brain

Shame, Stigma, and Culture Prevent Male Domestic Violence Survivors From Seeking Help

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