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microglia

Featured Neuroscience Open Neuroscience Articles

·April 7, 2019·4 min read

Microglia, cells thought restricted to central nervous system, are redefined in new study

In response to injury, microglia cross the spinal boundary from the central nervous system to the peripheral nervous system. While in the PNS, microglia provide the function of clearing cellular debris at the point of injury, then return to the CNS in an altered state. Researchers propose this could account for some damage associated with neurodegenerative diseases.

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Featured Neuroscience Open Neuroscience Articles

·March 31, 2019·4 min read

Allergic reactions play role in sexual behavior development in unborn males/females

Exposure to allergic inflammation, while in utero, increased mast cell and microglia activation, leading to masculinization of dendritic spine density in the preoptic area of females. During adulthood, females exposed to allergic inflammation showed an increase in more masculine behaviors.

Featured Neuroscience

·March 2, 2019·3 min read

Clues to Brain Differences Between Males and Females

A new study reveals how male sex steroids impact brain development. The findings could help shed light on behavioral developmental differences between males and females.

Featured Neurology

·February 20, 2019·6 min read

Can a Nerve Injury Trigger ALS?

A new study reveals peripheral nerve damage may trigger the onset and spread of ALS in mouse models of the neurodegenerative disease.

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·February 20, 2019·4 min read

Young Bone Marrow Rejuvenates Aging Brains: Mouse Study

Researchers report transplanting bone marrow from young mice to older mice helps to preserve memory and learning skills. If the findings can be replicated in humans, researchers believe new therapies can be devised to help combat disorders associated with brain aging.

Featured Genetics Neurology Neuroscience

·February 19, 2019·5 min read

Researchers Create New Map of Brain’s Immune System

Researchers have successfully created a new map of the brain's immune system in both mice and humans. The findings suggest microglia all have the same core signatures, but can act differently, depending on their function. The map also details how the brain's immune system changes as multiple sclerosis progresses.

Featured Neurology Neuroscience Neuroscience Videos Open Neuroscience Articles

·February 5, 2019·6 min read

New Scan Technique Reveals Neuroinflammation Associated with Post-Treatment Lyme Disease Syndrome

A new neuroimaging study reveals 12 people with documented post-treatment Lyme disease syndrome have an elevation of a chemical marker associated with neuroinflammation. The findings could help develop new treatments for the pain, fatigue and brain fog associated with PTLDS.

Featured Neuroscience Psychology

·February 4, 2019·5 min read

Excess Immune Pruning of Synapses in Neural Cells Derived From Patients with Schizophrenia

Researchers have directly observed excessive synaptic pruning in cells derived from people with schizophrenia.

Featured Genetics Neurology Neuroscience

·January 8, 2019·4 min read

New Genetic Risk Factor for Alzheimer’s Disease

A new study reveals a novel genetic risk loci for Alzheimer's disease. Using single cell gene expression patterns, researchers found genetic changes are expressed in microglia cells. The mutations are associated with an increased risk of Alzheimer's disease.

Featured Genetics Neurology

·January 8, 2019·4 min read

Defective Immune Cells in Brain May Cause Alzheimer’s

Researchers report therapeutic activation of the TREM2 gene during the early stages of Alzheimer's disease may help to counteract the formation of amyloid beta protein aggregates.

Featured Neurology Open Neuroscience Articles

·January 4, 2019·5 min read

Fungi Causes Brain Infection and Memory Impairments: Mouse Study

Researchers report a common yeast infection can cross the blood-brain barrier, triggering an inflammatory response that results in the formation of granuloma type structures and temporary memory impairments in mice.