Pernicious anemia is an autoimmune disorder associated with vitamin B12 deficiency. The condition not only affects physical health, it also has a detrimental effect on the mental health of many who suffer from the condition.
A newly identified neural network in the hippocampal formation plays a critical role in memory and object-location learning. The findings are highly relevant to learning and memory disorders, including Alzheimer's disease.
Middle-aged and older people who stay mentally active have a lower risk of developing mild cognitive impairment.
A rare autoimmune disorder popularized by the autobiography and movie "Brain on Fire" is triggered by an attack on NMDA receptors. The disease occurs when antibodies attack NMDA receptors in the brain, leading to memory loss, intellectual changes, seizures, and death.
Senolytic drugs administered to mice reduced senescent cells around amyloid plaques by more than 90% and decreased neuroinflammation by 50%. Mice treated with the drug combination also showed improvements in spatial memory, compared to other Alzheimer's model mice who received no treatment. The findings could have positive implications for the treatment of Alzheimer's disease in people with the condition.
During sepsis, the body sheds fragments of heparan sulfate, which crossed the blood-brain barrier and enters the hippocampus. The presence of heparan sulfate in the hippocampus may cause memory loss associated with septic shock.
Transcranial magnetic stimulation applied to the parietal lobe improves the function of brain areas important for memory which are disrupted by aging. The study reports TMS helps improve memory in older adults experiencing memory loss to the level of younger adults.
Researchers have developed new therapeutic molecules that appear to assist in reversing memory loss associated with depression and aging.
Researchers have identified a potential new biomarker for cognitive decline associated with Alzheimer's disease. The study reports fibrinogen, a blood clotting protein, causes a series of molecular events that may trigger the destruction of connections between neurons, resulting in cognitive decline.
A new study links poor sleep quality in older adults with elevated levels of tau, a protein associated with Alzheimer's disease. Researchers report poor sleep quality later in life may be associated with declining brain health and may be an early indicator of Alzheimer's disease.