A rare autoimmune disorder popularized by the autobiography and movie "Brain on Fire" is triggered by an attack on NMDA receptors. The disease occurs when antibodies attack NMDA receptors in the brain, leading to memory loss, intellectual changes, seizures, and death.
Blocking VCAM1 increased neurogenesis, and reduced microglia reactivity in the hippocampus of older mice.
Senolytic drugs administered to mice reduced senescent cells around amyloid plaques by more than 90% and decreased neuroinflammation by 50%. Mice treated with the drug combination also showed improvements in spatial memory, compared to other Alzheimer's model mice who received no treatment. The findings could have positive implications for the treatment of Alzheimer's disease in people with the condition.
During sepsis, the body sheds fragments of heparan sulfate, which crossed the blood-brain barrier and enters the hippocampus. The presence of heparan sulfate in the hippocampus may cause memory loss associated with septic shock.
Transcranial magnetic stimulation applied to the parietal lobe improves the function of brain areas important for memory which are disrupted by aging. The study reports TMS helps improve memory in older adults experiencing memory loss to the level of younger adults.
Researchers have developed new therapeutic molecules that appear to assist in reversing memory loss associated with depression and aging.
Researchers have identified a potential new biomarker for cognitive decline associated with Alzheimer's disease. The study reports fibrinogen, a blood clotting protein, causes a series of molecular events that may trigger the destruction of connections between neurons, resulting in cognitive decline.
A new study links poor sleep quality in older adults with elevated levels of tau, a protein associated with Alzheimer's disease. Researchers report poor sleep quality later in life may be associated with declining brain health and may be an early indicator of Alzheimer's disease.
Researchers report histamines can help improve memory of objects up-to 25 days longer than normal in mice, as well as improving people's long term memory test scores. The study suggests taking histamines may help alleviate symptoms of memory disorders such as Alzheimer's and other dementias.
Study reports 34% of men who consumed more leafy vegetables, and 47% who regularly drank orange juice were less likely to develop poor cognitive skills than those who did not.
According to researchers, meditation and listening to music may help to alter biomarkers associated with cellular aging and Alzheimer's disease in adults experiencing memory loss.
Researchers report osterocalcin, a naturally occurring hormone, can help boost memory in aging mice. The findings pave the way for new treatments to help stave off, and possibly reverse memory loss in humans.