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MCI

·January 1, 2020·5 min read

Objective subtle cognitive difficulties predict amyloid accumulation and neurodegeneration

Amyloid accumulation occurs faster in those who have objectively-defined cognitive difficulties than older people who are considered to be cognitively normal. Mild cognitive impairment is also associated with faster hippocampal and entorhinal cortex atrophy.

Featured Neurology Neuroscience

·December 30, 2019·3 min read

What comes first, beta-amyloid plaques or thinking and memory problems?

Subtle changes in thinking and memory may appear before, or in conjunction with, the development of amyloid plaques.

Featured Neurology Neuroscience

·December 29, 2019·7 min read

Drugs that quell brain inflammation reverse dementia

Older mice given anti-inflammatory medication were better able to learn new tasks and became almost as adept at learning as mice half their age.

Featured Neurology Neuroscience

·December 4, 2019·6 min read

Drugs that quell brain inflammation reverse dementia

A synthesized small-molecule drug blocks the TGF-beta receptor in astrocytes and traverses the blood-brain barrier in mice. When administered, the drug lowered receptor activity to that seen in younger mice and reduced inflammation. The aged mice were able to navigate mazes and learn spatial tasks as well as younger mice.

This shows an older couple riding bicycles

Featured Neurology Neuroscience Open Neuroscience Articles

·November 29, 2019·5 min read

Aerobic exercise and heart-healthy diet may slow development of memory problems

Combining aerobic exercise with the heart-healthy DASH diet improved the ability to think, recall, and make decisions in older people who experienced cognitive decline and mild cognitive impairment.

Featured Neurology Neuroscience

·October 28, 2019·3 min read

Looking at the way we walk can help predict cognitive decline

Gait disorders and slowed walking speeds may be useful indicators of future cognitive decline.

This is an illustration of amyloid beta in neurons

Featured Neurology Neuroscience

·September 17, 2019·5 min read

Exercise could slow withering effects of Alzheimer’s

For those with mild cognitive impairment (MCI) and other risk factors for Alzheimer's disease, participating in aerobic exercise several times a week may slow neurodegeneration. Aerobic exercise reduced hippocampal atrophy in those with MCI.

Featured Genetics Neurology Neuroscience

·September 15, 2019·3 min read

How the eyes might be windows to the risk of Alzheimer’s disease

Adults with mild cognitive impairment (MCI), a precursor to Alzheimer's disease, have greater pupil dilation when taking cognitive tests than their cognitively normal peers. Task-evoked pupillary response may be a cost-effective, and low invasive screening test for those at genetic risk for Alzheimer's before the symptoms of the disease take hold.

Featured Neurology Neuroscience Open Neuroscience Articles

·September 3, 2019·4 min read

Diet’s effect on gut bacteria could play role in reducing Alzheimer’s risk

A modified Mediterranean-ketogenic diet can modulate the gut microbiome and metabolites associated with improvements in Alzheimer's disease biomarkers.

Featured Neurology Neuroscience

·August 16, 2019·4 min read

Adults with mild cognitive impairment can learn and benefit from mindfulness meditation

Older adults with mild cognitive impairment who practiced mindful meditation for 20 minutes a day were more likely to have an understanding of the underlying concepts of mindfulness. The study demonstrates memory impairments associated with MCI do not preclude learning mindfulness skills.