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LRRK2

This shows a brain surrounded by viruses and DNA.

·August 31, 2025·5 min read

Could a Common Virus Help Drive Parkinson’s?

New research suggests a previously harmless virus may be linked to Parkinson’s disease. Scientists detected Human Pegivirus (HPgV) in the brains and spinal fluid of Parkinson’s patients but not in controls, challenging assumptions that the virus is benign.

Featured Neurology Neuroscience Open Neuroscience Articles

·March 21, 2022·4 min read

New Targets for Treating Parkinson’s Disease Discovered

People with Parkinson's disease have a clear genetic signature of the disease in their memory T-cells.

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·December 16, 2021·4 min read

Parkinson’s Disease Mutation Misdirects Iron in the Brain

Findings reveal a common Parkinson's disease genetic mutation drives mislocalization of iron in activated microglia.

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·August 3, 2021·3 min read

Repair of Mitochondrial Recycling Defect Linked to Parkinson’s Disease

An experimental small molecule helped restore the removal of mitochondria from dopamine-producing neurons in the brain. The findings may help in the development of new therapies for Parkinson's disease.

Featured Genetics Neurology Open Neuroscience Articles

·October 1, 2020·4 min read

Even in People With Parkinson’s Gene, Coffee May Be Protective

For carriers of the Parkinson's related LRRK2 gene, coffee consumption can help lower the risk of developing symptoms of the disease.

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·May 3, 2019·4 min read

New method developed to target cause of Parkinson’s

Clioquinol, an anti-parasitic medication, overcomes the effect of mutations in the LRRK2 gene associated with Parkinson's disease by restoring the acidity of lysosomes and clearing out protein aggregates.

This shows the chemical structure of vitamin b12

Featured Genetics Neurology Neuroscience

·April 4, 2019·3 min read

Vitamin B12 identified as the inhibitor of a key enzyme in hereditary Parkinson’s disease

Vitamin B12 significantly prevents the neurotoxicity of LRRK2 genetic variants associated with hereditary Parkinson's disease. The findings may help with the development of new therapies to combat the neurodegenerative disease.

Featured Neurology Neuroscience Open Neuroscience Articles

·January 10, 2019·4 min read

Defective Glial Cells Can Push Neurons Toward Parkinson’s Disease

A new study reveals a defective version of astrocytes may be linked to the build up of alpha synuclein and could spur Parkinson's disease. The findings show the important role glial cells play in Parkinson's and offers insights into new targets for therapies to fight the neurodegenerative disease.

Featured Neurology

·May 24, 2018·3 min read

Early Synaptic Dysfunction Found in Parkinson’s Disease

Mutations in LRRK2 leads to dysfunctional auxilin and impaired synaptic vesicle endocytosis in Parkinson's patients, researchers report.

Featured Genetics Neurology Open Neuroscience Articles

·May 22, 2018·4 min read

Link Between Tuberculosis and Parkinson’s Disease Discovered

Studying what the LRRK2 gene does in macrophages infected with the bacterium that causes tuberculosis, researchers believe they may have identified a cause of Parkinson's disease.

Featured Genetics Neurology

·March 21, 2018·4 min read

Parkinson’s Gene Initiates Disease Outside of the Brain

A new study reveals the LRRK2 genetic mutation may alter cells circulating outside of the brain. Researchers report the mutation may alter how immune cells react to common illnesses, causing an inflammatory reaction in the brain that can lead to the development of Parkinson's disease.

Featured Genetics Neurology

·October 26, 2017·4 min read

Parkinson’s Gene Needed For Dopamine Neuron Health

A new study reveals LRRK is essential for the survival of dopamine neurons in the brain. The finding may prompt new treatments for Parkinson's disease.

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LRRK2

Could a Common Virus Help Drive Parkinson’s?

New Targets for Treating Parkinson’s Disease Discovered

Parkinson’s Disease Mutation Misdirects Iron in the Brain

Repair of Mitochondrial Recycling Defect Linked to Parkinson’s Disease

Even in People With Parkinson’s Gene, Coffee May Be Protective

New method developed to target cause of Parkinson’s

Vitamin B12 identified as the inhibitor of a key enzyme in hereditary Parkinson’s disease

Defective Glial Cells Can Push Neurons Toward Parkinson’s Disease

Early Synaptic Dysfunction Found in Parkinson’s Disease

Link Between Tuberculosis and Parkinson’s Disease Discovered

Parkinson’s Gene Initiates Disease Outside of the Brain

Parkinson’s Gene Needed For Dopamine Neuron Health

Animal-Free Brain Tissue Breakthrough Could Transform Drug Testing

Next-Gen Wearable Lets You Control Machines with Simple Gestures

Quitting Impossible Goals May Actually Boost Wellbeing

How Mounjaro Alters Craving Circuits in the Brain

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