Researchers find a previously unknown connection between ALS, FTD, and the Huntington's disease associated gene, huntingtin. Read More
A mutated form of the huntingtin protein disrupts the normal movement of vesicles holding HT and Rab4. This leads to defects in synapses, resulting in movement abnormalities and lifespan decreases in fruit fly larvae. Findings suggest Rab4 could be a novel therapeutic target for the early intervention of Huntington's disease, before the neuronal loss and behavioral deficits associated with the neurodegenerative disorder. Read More
Mouse models of corticospinal injuries reveal adult neurons begin a natural regeneration process by reverting back to an embryonic state. The regeneration is sustained with the help of a gene more commonly associated with Huntington's disease. Read More
Researchers say the Huntingtin gene affects brain development from an early age, even though most patients do not develop Huntington's disease until later life. Read More
Researchers have identified a mechanism that may reduce the toxic aggregation of the huntingtin protein. The findings could lead to new treatment options for Huntington's patients. Read More
Restricting access to food within a strict time frame stimulates autophagy and lowers levels of the huntingtin protein in the brain, a new mouse study reveals. Read More
A new study reports researchers have developed a new gene editing approach that may provide a new treatment avenue for Huntington's disease. Read More
Researchers have decoded the 3D structure of the Huntingtin protein. The discovery may help develop new treatments for Huntington's disease. Read More
Rockefeller University researchers reveal Huntington's neurons are much larger than healthy cells. Read More
UCL researchers report clinical trials of IONIS-HTTRx have shown success in reducing the huntinting protein in the nervous system of those with Huntington's disease. The drug is safe and well tolerated by human patients, the researchers note. Read More
Findings may explain how neurodegenerative diseases spread throughout the brain and disrupt normal functions. Additionally, treatment for one disease could possibly work for the other two also. Read More
Researchers discover a link between neural tube defects and neurodegenerative diseases. Read More
