huntingtin

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huntingtin

·October 5, 2021·4 min read

Study Detects Origins of Huntington’s Disease in Two-Week-Old Human Embryos

Synthesizing a human embryo from stem cells and using gene editing to insert the Huntingtin gene, researchers found the mutation affected the size of germ layers compared to the control embryos. Findings suggest Huntington's disease may be a neurodevelopmental disorder that presents as a neurodegenerative disease later

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Featured Genetics Neurology Open Neuroscience Articles

·March 6, 2021·4 min read

Huntington’s Disease Driven by Slowed Protein-Building Machinery in Cells

The mutated huntingtin protein slows ribosome movement and decreases protein synthesis.

Featured Genetics Neurology Neuroscience

·December 6, 2020·4 min read

Study Links Cases of ALS and FTD to a Huntington’s Disease-Associated Mutation

Researchers find a previously unknown connection between ALS, FTD, and the Huntington's disease associated gene, huntingtin.

Featured Genetics Neurology Open Neuroscience Articles

·July 18, 2020·5 min read

Study Reveals Intricate Details About Huntington’s Disease Protein

A mutated form of the huntingtin protein disrupts the normal movement of vesicles holding HT and Rab4. This leads to defects in synapses, resulting in movement abnormalities and lifespan decreases in fruit fly larvae. Findings suggest Rab4 could be a novel therapeutic target for the early intervention of Huntington's disease, before the neuronal loss and behavioral deficits associated with the neurodegenerative disorder.

Featured Genetics Neurology Neuroscience

·April 15, 2020·4 min read

When damaged, the adult brain repairs itself by going back to the beginning

Mouse models of corticospinal injuries reveal adult neurons begin a natural regeneration process by reverting back to an embryonic state. The regeneration is sustained with the help of a gene more commonly associated with Huntington's disease.

Featured Genetics Neurology

·September 3, 2018·3 min read

Huntington’s Disease Starts in Childhood

Researchers say the Huntingtin gene affects brain development from an early age, even though most patients do not develop Huntington's disease until later life.

Featured Genetics Neurology Open Neuroscience Articles

·July 26, 2018·4 min read

System that Could Reduce Neurodegeneration in Huntington’s Discovered

Researchers have identified a mechanism that may reduce the toxic aggregation of the huntingtin protein. The findings could lead to new treatment options for Huntington's patients.

Featured Genetics Neurology Open Neuroscience Articles

·March 7, 2018·3 min read

Strict Eating Schedule Can Lower Huntington’s Protein: Mouse Study

Restricting access to food within a strict time frame stimulates autophagy and lowers levels of the huntingtin protein in the brain, a new mouse study reveals.

Featured Genetics Neurology Open Neuroscience Articles

·February 26, 2018·3 min read

One Step Closer to Treatment for Huntington’s

A new study reports researchers have developed a new gene editing approach that may provide a new treatment avenue for Huntington's disease.

Featured Genetics Neurology

·February 23, 2018·5 min read

Decoding the Structure of Huntintin

Researchers have decoded the 3D structure of the Huntingtin protein. The discovery may help develop new treatments for Huntington's disease.

Featured Genetics Neurology

·January 29, 2018·4 min read

Uncovering the Early Origins of Huntington’s Disease

Rockefeller University researchers reveal Huntington's neurons are much larger than healthy cells.

Featured Genetics Neurology

·December 12, 2017·2 min read

Drug Lowers Deadly Huntington’s Protein

UCL researchers report clinical trials of IONIS-HTTRx have shown success in reducing the huntinting protein in the nervous system of those with Huntington's disease. The drug is safe and well tolerated by human patients, the researchers note.

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