Researchers use a novel co-culturing method to create functional circuits that model Huntington's disease and find new clues to potential treatment approaches.
Researchers discover a novel factor which suppresses misfolding and aggregation of the huntingtin protein.
A new study points to a functional connection between mTOR and huntingtin.
Researchers report huntingtin plays a critical role in long-term memory.
Researchers work to understand how expanded polyglutamine tracts form the types of supramolecular structures that are presumed to be toxic to neurons.
Researchers have developed a new way in which to measure the shape of the huntingtin protein in living cells.
A new study indicates that quickly clearing away defective proteins in the brain could help prevent some neurodegenerative disorders.
Researchers discover a three molecule complex could be a target for treating Huntington's Disease, a genetic and currently incurable brain disease which causes movement disorders and dementia.
A new light-based technique for measuring levels of the toxic protein that causes Huntington's disease (HD) has been used to demonstrate that the protein builds up gradually in blood cells.
HD mice crossbred with mice that produced greater levels of PGC-1alpha showed dramatic improvement. Production of misfolded proteins was essentially eliminated and the mice behaved normally. “Degeneration of brain cells is prevented. Neurons don’t die,” said La Spada.
‘HD in a dish’ will facilitate search for elusive treatment. An international consortium of Huntington’s disease experts, including several from...
