‘HD in a dish’ will facilitate search for elusive treatment. An international consortium of Huntington’s disease experts, including several from...
HD mice crossbred with mice that produced greater levels of PGC-1alpha showed dramatic improvement. Production of misfolded proteins was essentially eliminated and the mice behaved normally. “Degeneration of brain cells is prevented. Neurons don’t die,” said La Spada.
A new light-based technique for measuring levels of the toxic protein that causes Huntington's disease (HD) has been used to demonstrate that the protein builds up gradually in blood cells.
Researchers discover a three molecule complex could be a target for treating Huntington's Disease, a genetic and currently incurable brain disease which causes movement disorders and dementia.
Researchers have developed a new way in which to measure the shape of the huntingtin protein in living cells.
Researchers report huntingtin plays a critical role in long-term memory.
A new study points to a functional connection between mTOR and huntingtin.
Researchers discover a novel factor which suppresses misfolding and aggregation of the huntingtin protein.
Researchers use a novel co-culturing method to create functional circuits that model Huntington's disease and find new clues to potential treatment approaches.