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Genetics

·June 13, 2025·3 min read

Different Autism Genes, Same Brain Signature

New research shows that different genetic forms of autism may produce a shared brain activity pattern, revealing a potential common neural signature despite distinct genetic origins. Using brain-wide recordings in preclinical models, scientists observed that autism-linked mutations affected how expectations are updated during decision-making.

This shows a person on a treadmill and neurons.

Featured Genetics Neurology Neuroscience

·June 13, 2025·5 min read

Exercise Rewires Alzheimer’s-Affected Brain Cells

Using cutting-edge RNA sequencing, researchers mapped how exercise affects specific brain cell types in a model of Alzheimer’s disease. They found that physical activity alters gene activity in microglia and a newly identified type of astrocyte linked to blood vessels, which may protect memory.

Featured Genetics Neuroscience Psychology

·June 12, 2025·4 min read

Social Status and Genes Interact to Shape the Aging Brain

A global study of nearly one million individuals has identified hundreds of genetic regions linked to socioeconomic status, revealing a shared genetic signal across income, education, occupation, and deprivation. Researchers found that about 9% of the variation in socioeconomic status could be attributed to genetics, while the rest was driven by social and environmental factors.

Featured Genetics Neuroscience Psychology

·June 12, 2025·4 min read

Stress Genes Guide Cell Cleanup

New research has uncovered how the body clears dying cells during times of stress, shedding light on the unexpected role of classic stress-response genes. Using the model organism C. elegans, scientists tracked how these genes activate a pathway that helps remove cellular debris, a process essential for immune health and development.

Featured Genetics Neurology Neuroscience

·June 12, 2025·5 min read

Healthy Habits May Offset Brain Aging Linked to Shorter Telomeres

New research shows that healthy lifestyle choices can reduce the risk of stroke, dementia, and depression—even in people with biologically shortened telomeres. Telomeres are protective DNA caps that naturally shrink with age and environmental stress, increasing vulnerability to age-related brain diseases.

Featured Genetics Neurology Neuroscience

·June 11, 2025·7 min read

New Map Reveals First Steps of Protein Clumping in Alzheimer’s

Scientists have mapped how over 140,000 mutations affect the formation of amyloid beta fibrils, offering an unprecedented look at early events in Alzheimer’s disease. By combining DNA synthesis, genetically engineered yeast, and machine learning, they built a detailed energy landscape of the protein’s transition state—an elusive moment before plaque formation begins.

Autism Featured Genetics Neuroscience

·June 11, 2025·5 min read

Hidden Protein Defects Behind Autism Identified

Researchers have created a standardized mouse stem cell library containing 63 genetic variants strongly linked to autism spectrum disorder. Using CRISPR gene editing, the team generated mice and diverse tissues from these modified cells, allowing them to model autism at both the cellular and organismal level.

Featured Genetics Neuroscience

·June 10, 2025·4 min read

How the Brain’s RNA Rings Are Formed

Circular RNAs (circRNAs) are stable, ring-shaped molecules that play crucial roles in brain development, cognition, and long-term cellular regulation. Unlike typical RNA, they form closed loops that resist degradation, making them ideal for neurons.

Featured Genetics Neuroscience Psychology

·June 10, 2025·6 min read

Genetic Sensitivity to Environment May Shape Mental Health Traits

A large international study of over 21,000 identical twins has identified genetic variants that influence how individuals respond to life experiences, affecting traits such as anxiety, depression, and autistic traits. By analyzing genetic differences in identical twins, researchers discovered that certain genes make people more or less sensitive to environmental exposures.

Featured Genetics Neuroscience

·June 6, 2025·4 min read

Skin Aging Reduced by Molecules from Bacteria in the Blood

Researchers have identified three anti-aging compounds produced by Paracoccus sanguinis, a bacterium found in the bloodstream. These indole-based metabolites reduced inflammation and oxidative stress in human skin cell cultures—key contributors to skin aging.

Featured Genetics Neurology Neuroscience

·June 5, 2025·7 min read

HIV Drugs Linked to Lower Alzheimer’s Risk

FDA-approved HIV drugs targeting reverse transcriptase (RT) may reduce Alzheimer’s risk by blocking similar enzymatic activity in the aging brain. Scientists discovered unexpected RT activity in neurons of healthy and Alzheimer’s brains, tracing it to truncated LINE1 elements—ancient genetic sequences capable of copying themselves via RT.

Featured Genetics Neuroscience

·June 3, 2025·6 min read

Dormant Stem Cells May Hold Key to Restoring Sense of Smell

Researchers have created a 3D mouse organoid model to study how neurons in the nose regenerate, revealing that a type of stem cell once considered dormant may be crucial for repairing olfactory tissue. The team found that horizontal basal cells (HBCs), marked by KRT5, actively support new neuron generation alongside globose basal cells (GBCs).