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DIPG

Brain Cancer Featured Neurology Neuroscience

·June 14, 2024·4 min read

New Insights into Pediatric Brain Tumors

Researchers have advanced the understanding of pediatric DIPG tumors. DIPG, a highly aggressive brain tumor in children, is driven by the H3K27M mutation and resists radiation therapy.

Brain Cancer Featured Genetics Neurology Neuroscience

·November 21, 2019·7 min read

Scientists find promising drug combination against lethal childhood brain cancers

Researchers have discovered a pair of drugs that work together to kill cancer cells and counter genetic mutations that cause diffuse midline gliomas.

Brain Cancer Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·May 16, 2019·4 min read

Mutations Synergize in Pediatric Brain Cancer

The epigenetic histone mutation H3.1K27M works in combination with ACVR1 mutations to cause diffuse intrinsic pontine glioma tumors to form and grow quickly.

Brain Cancer Featured Neurology Neuroscience

·April 6, 2019·4 min read

New hope for treating childhood brain cancer

DIPG cancer cells exposed to MI-2 fail to maintain healthy levels of cholesterol and die quickly, by inhibiting lanosterol synthase. Additionally, while MI-2 destroys glioma cancer cells, the drug does not damage healthy brain cells.

Brain Cancer Featured Neurology

·April 17, 2018·4 min read

Possible Novel Method for Stopping Untreatable Pediatric Brain Cancers

A small molecule, 6-thio-dG, may provide a new approach to treating currently untreatable pediatric brain cancers, researchers report.

Brain Cancer Featured Neurology

·April 16, 2018·8 min read

Altered Immune Cells Clear Childhood Brain Tumor: Mouse Study

A fatal brain stem tumor was cleared by injecting it with engineered T-cells that recognized cancer and targeted it for destruction in mouse models, researchers report.

Image shows a brain scan from a cancer patient.

Brain Cancer Featured Neurology Open Neuroscience Articles

·September 28, 2017·8 min read

Study Splits Incurable Childhood Brain Tumors Into 10 New Diseases

Based on a large scale meta analysis, researchers report striking differences between children's high grade gliomas, so much so that they could be split into 10 different subtypes based on different characteristics. The findings have important implications for developing new and individualized treatments.