Mutations Synergize in Pediatric Brain Cancer
The epigenetic histone mutation H3.1K27M works in combination with ACVR1 mutations to cause diffuse intrinsic pontine glioma tumors to form and grow quickly.... Read More...
DIPG
New hope for treating childhood brain cancer
DIPG cancer cells exposed to MI-2 fail to maintain healthy levels of cholesterol and die quickly, by inhibiting lanosterol synthase. Additionally, while MI-2 destroys glioma cancer cells, the drug does not damage healthy brain cells.... Read More...
Possible Novel Method for Stopping Untreatable Pediatric Brain Cancers
A small molecule, 6-thio-dG, may provide a new approach to treating currently untreatable pediatric brain cancers, researchers report.... Read More...
Altered Immune Cells Clear Childhood Brain Tumor: Mouse Study
A fatal brain stem tumor was cleared by injecting it with engineered T-cells that recognized cancer and targeted it for destruction in mouse models, researchers report. ... Read More...
Study Splits Incurable Childhood Brain Tumors Into 10 New Diseases
Based on a large scale meta analysis, researchers report striking differences between children's high grade gliomas, so much so that they could be split into 10 different subtypes based on different characteristics. The findings have important implications for developing new and individualized treatments. ... Read More...
Hitting the Breaks on Lethal Brain Cancers
Targeting a protein called neuroligin 3 helps stop the growth of high grade gliomas in mice, a new study reports.... Read More...
PET/CT Helps Predict Therapy Effectiveness in Pediatric Brain Tumors
Researchers use PET neuroimaging technology to help determine which children with DIPG brain cancer will benefit best from Avastin.... Read More...
Experimental Therapy Halts Treatment Resistant Brain Tumors
Researchers report an experimental treatment has shown to be able to stop treatment resistant glioblastoma in human cells and mouse models.... Read More...
Epigenetic Drugs Could be Used to Treat Deadly Pediatric Cancer
A new study reports panobinostat and other gene regulating drugs may prove helpful in the treatment of DIPG.... Read More...