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          This shows the outline of a head
          FeaturedGeneticsNeurologyNeuroscience
          ·January 30, 2023·5 min read

          How Our Brains Turn Into Smarter Disease Fighters

          CRISPR gene editing created the G795A amino acid which was introduced to microglia derived from human stem cells. Researchers were able to transplant the donor microglia immune cells into humanized rodent models while administering an FDA-approved cancer drug called pexidartinib. The inclusion of the amino acid cause the donated microglia to thrive and resist the drug, while the host microglia died. The findings open the door for new methods of using microglia to treat a range of neurodegenerative disorders.
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          FeaturedGeneticsNeurologyNeuroscienceOpen Neuroscience Articles
          ·January 25, 2023·4 min read

          Drug That Targets Tauopathies in Mice Reveals Sex Differences in Response

          Exposure to drugs that target tauopathies extended survival, reduced neurodegenerative biomarkers, and functionally reduced aberrant behaviors in female mice, but not in males.
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          FeaturedGeneticsNeurologyNeuroscience
          ·December 30, 2020·4 min read

          Mutations Associated With Early Onset Dementia Discovered

          Disruptions in circulating white blood cells may be a key driver in ALSP, a rare form of early-onset dementia.
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          This shows brain slices from the research paper
          FeaturedGeneticsNeurologyNeuroscience
          ·February 24, 2020·4 min read

          ‘Resetting’ immune cells improves traumatic brain injury recovery

          By inhibiting a particular receptor microglia use to survive, researchers reduced neuroinflammation and prompted recovery following traumatic brain injury in mouse models.
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          This shows neurons
          FeaturedNeurologyNeuroscienceOpen Neuroscience Articles
          ·August 21, 2019·3 min read

          Link between brain immune cells and Alzheimer’s disease development identified

          The brain's immune cells may contribute to the development of Alzheimer's disease. Turning off microglia in specific areas of the brain prevented the formation of amyloid plaques. The findings could help pave the way for new treatments for Alzheimer's.
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          pyramidal neurons
          FeaturedNeurologyOpen Neuroscience Articles
          ·September 3, 2018·4 min read

          Big Data Approach to Drug Discovery Leads to New Epilepsy Target

          CRAFT, a new computational framework designed to aid in drug discovery, has helped researchers identify a potential new target for the treatment of epilepsy.
          Read More
          Image shows brain tissue.
          FeaturedNeurology
          ·February 29, 2016·3 min read

          Improving Memory in Alzheimer’s by Blocking Inflammation

          Researchers have disarmed the brain's response to amyloid beta using a compound used to treat cancer, a new study reports.
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          Image shows an alzheimer's brain.
          FeaturedNeurologyOpen Neuroscience Articles
          ·January 8, 2016·4 min read

          Blocking Brain Inflammation Could Protect Memory For Alzheimer’s Patients

          Reducing brain inflammation could help to halt the progression of Alzheimer's disease, researchers report.
          Read More

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          Exercise Mitigates Genetic Risk for Type 2 Diabetes

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          Boosting Infant Brains: Parental Speech Enhances Baby’s Development

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          Mosaic Mutations Reveal New Insights into Bipolar Disorder

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          Visualizing Brain Synapse Strength With AI

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