Exposing mice to THC, researchers noted persistent activation of mitochondrial cannabinoid receptors located within astrocytes resulted in a cascade of molecular processing that led to dysfunctional glucose metabolism. The ability of astrocytes to transform glucose into "food" for neurons was reduced. The reduction resulted in a compromise in neural function, with a harmful impact on behavior. Specifically, social interactions were reduced for 24 hours post cannabis exposure.
The secretory pathway delivery of cannabinoid type 1 receptor is axonally based, and surface expressed CB1R is more stable in axons than dendrites.
A new study reports cannabis can prune synapses and destroy some neural circuits.
The findings could provide new insights into brain diseases such as Alzheimer's, schizophrenia and depression.
Researchers report the 'love hormone', oxytocin, could enhance the pleasure of social interactions be stimulating the production of anandamide.
Researchers report on the role type 1 cannabinoid receptors play in controlling negative memories.
A new study reports extremely low levels of THC could slow, or even halt, the progression of Alzheimer's disease.
Cannabinoid receptors have been identified in the central nucleus of the amygdala, a key emotional hub in the brain.