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Summary: Researchers have synthesized THC molecules that can be altered by light.
Source: ETH Zurich.
When many people hear the abbreviation THC (tetrahydrocannabinol), they immediately think of smoking marijuana and intoxication. But the substance is also of interest to medicine – when given to people suffering from serious illnesses, it relieves muscle cramps, pain, loss of appetite and nausea.
THC works by binding to the corresponding cannabinoid-1 (CB1) receptors, which are located in the cell membrane and are present in large numbers in the central and peripheral nervous system. CB1 receptors play a major role in memory, motor coordination, mood and cognitive processes. Receptors key to signal transmission
When a THC molecule binds to one of these CB1 receptors, it changes form, triggering a cascade of various signals inside the cell. However, it is still hard to study CB1 receptors and their manifold functions, because cannabinoids such as THC are highly lipophilic, so they frequently embed themselves in the membranes made of fat molecules in an uncontrolled manner. To be able to use THC or variants of it more precisely for pharmaceutical and medical applications, it is therefore important to gain a better understanding of CB1 receptors.
To study the diverse interactions between CB1 receptors and cannabinoids, a group of chemists headed by ETH professor Erick Carreira synthesised THC molecules. Their structure can be altered with light. The researchers published their findings in the latest issue of the Journal of the American Chemical Society.
Light-sensitive THC derivatives
The scientists synthesised four variants, or derivatives, of THC by attaching a light-sensitive “antenna” to the THC molecule. This antenna makes it possible to use light of a specific wavelength to precisely manipulate the altered molecule. Ultraviolet light changes the spatial structure of the antenna, and this change can be reversed again with blue light.
The researchers tested two of these derivatives in a living cell culture. The derivatives docked with CB1 receptors in the same way as naturally occurring THC. When the researchers irradiated the THC derivative with ultraviolet light, its structure altered just as the researchers expected, consequently activating the CB1 receptor. This triggers reactions such as the opening of the potassium ion channels located in the cell membrane, which causes potassium ions to flow out of the cell. The researchers were able to measure this with an electrode inserted into the cell.
When irradiated with blue light, the THC derivative returned to its original form, disabling the CB1 receptor as a result. The ion channels closed and the flow of potassium stopped. The researchers were able to activate and deactivate these processes using the corresponding coloured pulses of light. A basis for light-controlled applications
“This work is our successful proof of principle: light-sensitive THC variants are a suitable tool for controlling and influencing CB1 receptors,” says Michael Schafroth, a doctoral student with ETH professor Carreira and major contributor to the study. He added that they have now laid an important foundation for further projects that are already in progress; for example, another doctoral student in Carreira’s group, Roman Sarott, is working on synthesising additional THC derivatives that react to long-wavelength red light. “Red light penetrates deeper into tissue than blue light,” says Sarott. “If we want to study CB1 receptors in a living organism, we need molecules that are sensitive to red light.”
In addition to the researchers from Carreira’s group, leading scientists from New York University (NYU), the Indiana University Bloomington (IUB) and the University of Southern California (USC) as well as the Ludwig-Maximilian University in Munich were involved in the interdisciplinary project. The biological experiments were conducted by James Frank and Dirk Trauner. A starting point for medicine
Many cultures have long known of the intoxicating and therapeutic effect of THC. The identification of THC eventually led to the discovery of the endocannabinoid system, which involves the body’s native as well as exogenous substances in the cannabinoids class as well as their receptors in the body.
The pharmaceutical industry is also interested in gaining a better understanding of the endocannabinoid system so that it can better use specific components for pharmaceutical purposes. The system is considered a possible starting point for treatments for addiction, obesity, depression and even Alzheimer’s and Parkinson’s.
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Source: Erick Carreira – ETH Zurich Publisher: Organized by NeuroscienceNews.com. Image Source: NeuroscienceNews.com image is in the public domain. Original Research: Abstract for “Synthesis of Photoswitchable Δ9-Tetrahydrocannabinol Derivatives Enables Optical Control of Cannabinoid Receptor 1 Signaling” by Matthias V. Westphal, Michael A. Schafroth , Roman C. Sarott, Michael A. Imhof, Christian P. Bold, Philipp Leippe, Amey Dhopeshwarkar, Jessica M. Grandner, Vsevolod Katritch , Ken Mackie, Dirk Trauner, Erick M. Carreira, and James A. Frank in JACS. Published online November 21 2017 doi:10.1021/jacs.7b06456
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[cbtabs][cbtab title=”MLA”]ETH Zurich “Light Sensitive THC For Research.” NeuroscienceNews. NeuroscienceNews, 10 January 2018. <https://neurosciencenews.com/thc-light-sensitive-8296/>.[/cbtab][cbtab title=”APA”]ETH Zurich (2018, January 10). Light Sensitive THC For Research. NeuroscienceNews. Retrieved January 10, 2018 from https://neurosciencenews.com/thc-light-sensitive-8296/[/cbtab][cbtab title=”Chicago”]ETH Zurich “Light Sensitive THC For Research.” https://neurosciencenews.com/thc-light-sensitive-8296/ (accessed January 10, 2018).[/cbtab][/cbtabs]
Synthesis of Photoswitchable Δ9-Tetrahydrocannabinol Derivatives Enables Optical Control of Cannabinoid Receptor 1 Signaling
The cannabinoid receptor 1 (CB1) is an inhibitory G protein-coupled receptor abundantly expressed in the central nervous system. It has rich pharmacology and largely accounts for the recreational use of cannabis. We describe efficient asymmetric syntheses of four photoswitchable Δ9-tetrahydrocannabinol derivatives (azo-THCs) from a central building block 3-Br-THC. Using electrophysiology and a FRET-based cAMP assay, two compounds are identified as potent CB1 agonists that change their effect upon illumination. As such, azo-THCs enable CB1-mediated optical control of inwardly rectifying potassium channels, as well as adenylyl cyclase.
“Synthesis of Photoswitchable Δ9-Tetrahydrocannabinol Derivatives Enables Optical Control of Cannabinoid Receptor 1 Signaling” by Matthias V. Westphal, Michael A. Schafroth , Roman C. Sarott, Michael A. Imhof, Christian P. Bold, Philipp Leippe, Amey Dhopeshwarkar, Jessica M. Grandner, Vsevolod Katritch , Ken Mackie, Dirk Trauner, Erick M. Carreira, and James A. Frank in JACS. Published online November 21 2017 doi:10.1021/jacs.7b06456
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