In rheumatoid arthritis, inflammation in one joint is transmitted to other joints via the sensory neuron connections in the spinal cord, leading to inflammation in the other joints. Inflammation in one joint led to an increase in ATP in other joints, which triggered an increase of a signaling molecule that resulted in inflammation. Blocking the pathway reduced the spread of inflammation.
The sense of taste in female mosquitoes is specially tuned to detect at least four different substances in blood.
The retrieval of mitochondria via a feedback loop is vital to sustaining synaptic transmission.
Researchers have identified a bio-chemical circuit that supports neuron-microglia communication. When neurons are active, they release ATP. Microglia sense extracellular ATP and the compound draws the immune cell toward the neuron.
Microscopy study sheds light on the function of two calcium homeostasis modulators.
Using zebrafish models, researchers detected genes with altered levels of expression. The genetic variations were associated with abnormalities with mitochondrial function and the production of ATP.
Researchers have developed small molecules that inhibit one of the main enzymes implicated in autoimmune response. The research could lead to potential new medications for a range of autoimmune diseases.
Vitamin B12 significantly prevents the neurotoxicity of LRRK2 genetic variants associated with hereditary Parkinson's disease. The findings may help with the development of new therapies to combat the neurodegenerative disease.