Rapid Agent Restores Pleasure Seeking Ahead of Other Antidepressant Action
Treatment resistant bipolar disorder patients experienced a reversal of a key symptom 40 minutes after a single infusion of ketamine, a new study reports.... Read More...
anhedonia
Induction of Mild Inflammation Leads to Cognitive Deficits Related to Schizophrenia
Researchers have identified an exceptional mouse model of schizophrenia. The study identified a mutant mouse lacking the Schnurri-2 protein (Shn-2 KO) that exhibits behavioral deficits and other brain features consistent with schizophrenia.... Read More...
Why the Thrill is Gone: Scientists Identify Potential Target for Treating Major Symptom of Depression
Scientists have laid bare a novel molecular mechanism responsible for the major depression symptom, anhedonia, the loss of the ability to experience pleasure. The brain circuit involved in this newly elucidated pathway is largely identical between rodents and humans, upping the odds that the findings point toward new therapies for depression and other disorders. Additionally, opinion leaders hailed the study’s inventive methodology, saying it may offer a much sounder approach to testing new antidepressants.... Read More...