Scientists have laid bare a novel molecular mechanism responsible for the major depression symptom, anhedonia, the loss of the ability to experience pleasure. The brain circuit involved in this newly elucidated pathway is largely identical between rodents and humans, upping the odds that the findings point toward new therapies for depression and other disorders. Additionally, opinion leaders hailed the study’s inventive methodology, saying it may offer a much sounder approach to testing new antidepressants.
Researchers have identified an exceptional mouse model of schizophrenia. The study identified a mutant mouse lacking the Schnurri-2 protein (Shn-2 KO) that exhibits behavioral deficits and other brain features consistent with schizophrenia.
Treatment resistant bipolar disorder patients experienced a reversal of a key symptom 40 minutes after a single infusion of ketamine, a new study reports.
Researchers find high level of inflammation markers in the blood of people with depression. The research indicates persistent inflammation affects brain areas associated with the more stubborn symptoms of depression.
According to a new study, those addicted to cocaine have strong motivation to seek out rewards, but exhibit an impaired ability to adjust their behavior and are less fulfilled when they achieve their desired goal.
In depressed people, the habenula functions abnormally, a new study reports.
People with musical anhedonia have reduced connectivity between brain areas associated with reward and sound processing, a new study reports.
Stanford researchers have identified five new categories of specific symptoms and brain area activation that can be applied to the diagnosis of anxiety and depression in a more specific manner.
It is possible for those with anhedonia to enjoy experiences and feel pleasure, however, those with the disorder find it hard to maintain their positive emotions, a new study reports.
Researchers report cognitive bias modification may be a useful method for treating depression.