Exposing subjects to music composed in an unfamiliar scale, researchers test whether reward can be derived solely from newly formed predictions. Read More
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Using a drug used to help treat addiction, researcher report exposing people to their favorite songs no longer elicit feelings of pleasure. Read More
What we find pleasurable may be down to our genetics. Researchers found nucleus accumbens activation and physical anhedonia were influenced by shared genes. The experience of pleasure and physical anhedonia also appear to share some of the same genes. Read More
Researchers explain the neural mechanisms behind a person's lack of sensitivity to music. Read More
Stanford researchers have identified five new categories of specific symptoms and brain area activation that can be applied to the diagnosis of anxiety and depression in a more specific manner. Read More
Mu-opioid receptor (MOR) levels are significantly reduced in the striatum in those with schizophrenia. A lack of MOR system stimulation contributes to negative feelings, such as a lack of motivation and anhedonia, associated with the condition. Increasing MOR levels could help to reduce some of the symptoms of schizophrenia. Read More
Treatment resistant bipolar disorder patients experienced a reversal of a key symptom 40 minutes after a single infusion of ketamine, a new study reports. Read More
A fragment of the neuropeptide Galanin appears to play a role in anhedonia in mouse models of depression. Galanin could be a potential target for the treatment of depression. Read More
Researchers find high level of inflammation markers in the blood of people with depression. The research indicates persistent inflammation affects brain areas associated with the more stubborn symptoms of depression. Read More
In depressed people, the habenula functions abnormally, a new study reports. Read More
Researchers have identified an exceptional mouse model of schizophrenia. The study identified a mutant mouse lacking the Schnurri-2 protein (Shn-2 KO) that exhibits behavioral deficits and other brain features consistent with schizophrenia. Read More
Inflammation appears to reduce reward response in females. Reduced activity in the brain's reward system is a key component of anhedonia, the loss of enjoyment in activities, a core feature of depression. The findings may explain why depression is more prevalent in women than in men. Read More
