Irisin, a hormone secreted into the blood during high endurance and aerobic exercise, reduces levels of alpha-synuclein and restores movement in mouse models of Parkinson's disease.
Alpha-synuclein proteins form into unusual shapes when exposed to large quantities of copper ions. Researchers say the effect of environmental copper exposure on alpha-synuclein could play a role in the pathogenesis of Parkinson's disease.
The Parkinson's-associated protein alpha-synuclein appears to act as a "toggle switch" that helps control vesicle transportation and gene expression. In a diseased state, this delicate balance is broken. The findings have implications for the development of new treatments for Parkinson's disease.
Volume decreases in cortical areas, the amygdala, and basal forebrain in Parkinson's patients correlated with worsening symptoms of the disease.
A specific Parkinson's related gene could be a driver behind vocal production problems associated with the disease. The findings could lead to earlier diagnosis and treatment of Parkinson's disease.
People with Parkinson's disease have a clear genetic signature of the disease in their memory T-cells.
APOE proteins were enhanced in the brains of patients with dementia, even when they did not carry the Alzheimer's associated gene.
The COVID causing SARS-CoV-2 protein interacts with alpha-synuclein, speeding up the formation of amyloid plaques, a new study reports.
Microglia immune cells can join together to form networks when needed, a new study reports. However, certain mutations associated with Parkinson's disease can impair this process.
New findings reinforce the idea that dementia with Lewy bodies can be pathologically classified as two different and distinct disease types.
Chronic gut inflammation can trigger the clumping of alpha-synuclein in the walls of the colon, a new study reports. Researchers found chronic inflammation in the gut during early life can exacerbate the clumping of alpha-synuclein in the brains of older mice. The findings add to a growing body of evidence which links gut health to Parkinson's disease.
A new model of Parkinson's disease sheds light on the asymmetrical motor symptoms, and other disorders, associated with this disease.
