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alpha-synuclein

This shows the outline of two bodies. One has the head highlighted red, the other has the gut highlighted red

Where does Parkinson’s disease start? In the brain or gut? Or both?

Neuroscience News
Lewy body disorders, including Parkinson's disease and Lewy body dementia, comprise of two distinct subtypes. One subtype originates in the peripheral nervous system (PNS) of the gut and spreads to the brain. The other originates in the brain, or enters the brain via the olfactory system, before spreading to the brainstem and PNS.... Read More...
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This is a drawing of the intestines

Parkinson’s disease may originate in the intestines

Neuroscience News
Two months after injecting alpha-synuclein into the intestines of rats, researchers discovered the proteins had traveled to the brain via peripheral nerves. Four months later, the pathology was greater. Additionally, the protein had traveled to the heart. The study supports the hypothesis that Parkinson's disease may begin in the intestinal system before migrating to the brain. ... Read More...
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This diagram shows how a-synuclein travels from the gut to the brain via the vagus nerve

New research shows Parkinson’s disease origins in the gut

Neuroscience News
A new study adds to the growing body of evidence that Parkinson's disease may start in the gut. Researchers found gut-to-brain propagation of alpha-synuclein spread via the vagus nerve. The study provides a more accurate model of Parkinson's progression and could lead to new treatments to halt or prevent this neurodegenerative disease.... Read More...
FeaturedNeurologyNeuroscienceNeuroscience VideosOpen Neuroscience Articles8 min read