Similar But Different: New Discovery for Neurodegenerative Disease

Researchers from the University of Melbourne have established how two diseases that present in similar ways are in fact quite different.

Progressive Supranuclear palsy (PSP) and Parkinson’s Disease (PD) have overlapping symptoms but remain difficult to distinguish.

However, a first ever paper on the topic published in the Journal of Neuropsychology (British Psychological Society publication) now suggests that people with PSP experience more severe and extensive cognitive impairments than those with PD early on.

The study indicates that patients with PSP experience more severe and extensive impairments in higher order functions such as planning, abstract thinking, memory retrieval than those with PD.

Lead researcher Dr Young-Eun Claire Lee said the two conditions are so similar that in some cases, patients with PSP often go undiagnosed for the main part of their illness.

This image shows a brain on jigsaw pieces.
The study indicates that patients with PSP experience more severe and extensive impairments in higher order functions such as planning, abstract thinking, memory retrieval than those with PD. Credit University of Melbourne.

“PD and PSP are the two of the most common forms of neurodegenerative diseases resulting in loss of balance and deterioration in mobility,” said Dr Lee.

“Telling these differences apart can be challenging because most patients with PSP do not develop distinctive symptoms such as paralysis or weakness of the eye muscles and episodes of frequent falling until later stages,” she said.

While the study sample was small, the results indicate that cognitive profiles may aid differential diagnosis in earlier stages. PSP claimed the life of musician/actor Dudley Moore.

There are no current treatments for PSP.

Notes about this neurosdegeneration research

Contact: Anne Rahilly – University of Melbourne
Source: University of Melbourne press release
Image Source: The image is adapted from the University of Melbourne press release
Original Research: Abstract for “Frontal deficits differentiate progressive supranuclear palsy from Parkinson’s disease” by Young-Eun C. Lee, David R. Williams and Jacqueline F. I. Anderson in Journal of Neuropsychology. Published online September 16 2014 doi:10.1111/jnp.12053

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