2Summary: Researchers report sleep can help immune cells attach to targets and help fight infection. The study reveals how sleep assists the body in fighting infections, whereas conditions like chronic stress can make the body more susceptible to illness.Source: Rockefeller University Press.Researchers in Germany have discovered why sleep can sometimes be the best medicine. Sleep improves the potential ability of some of the body’s immune cells to attach to their targets, according to a new study that will be published February 12 in the Journal of Experimental Medicine. The study, led by Stoyan Dimitrov and Luciana Besedovsky at the University of Tübingen, helps explain how sleep can fight off an infection, whereas other conditions, such as chronic stress, can make the body more susceptible to illness.T cells are a type of white blood cell that are critical to the body’s immune response. When T cells recognize a specific target, such as a cell infected with a virus, they activate sticky proteins known as integrins that allow them to attach to their target and, in the case of a virally infected cell, kill it. While much is known about the signals that activate integrins, signals that might dampen the ability of T cells to attach to their targets are less well understood.Stoyan Dimitrov and colleagues at the University of Tübingen decided to investigate the effects of a diverse group of signaling molecules known as Gαs-coupled receptor agonists. Many of these molecules can suppress the immune system, but whether they inhibit the ability of T cells to activate their integrins and attach to target cells was unknown.Dimitrov and colleagues found that certain Gαs-coupled receptor agonists, including the hormones adrenaline and noradrenaline, the proinflammatory molecules prostaglandin E2 and D2, and the neuromodulator adenosine, prevented T cells from activating their integrins after recognizing their target. “The levels of these molecules needed to inhibit integrin activation are observed in many pathological conditions, such as tumor growth, malaria infection, hypoxia, and stress,” says Dimitrov. “This pathway may therefore contribute to the immune suppression associated with these pathologies.”Adrenaline and prostaglandin levels dip while the body is asleep. Dimitrov and colleagues compared T cells taken from healthy volunteers while they slept or stayed awake all night. T cells taken from sleeping volunteers showed significantly higher levels of integrin activation than T cells taken from wakeful subjects. The researchers were able to confirm that the beneficial effect of sleep on T cell integrin activation was due to the decrease in Gαs-coupled receptor activation.This diagram shows how the effects of Gαs-coupled agonists on T cells can be influenced by sleep or disease. NeuroscienceNews.com image is credited to Dimitrov et al., 2019.“Our findings show that sleep has the potential to enhance the efficiency of T cell responses, which is especially relevant in light of the high prevalence of sleep disorders and conditions characterized by impaired sleep, such as depression, chronic stress, aging, and shift work,” says last author Luciana Besedovsky.In addition to helping explain the beneficial effects of sleep and the negative effects of conditions such as stress, Dimitrov and colleagues’ study could spur the development of new therapeutic strategies that improve the ability of T cells to attach to their targets. This could be useful, for example, for cancer immunotherapy, where T cells are prompted to attack and kill tumor cells.[divider]About this neuroscience research article[/divider]Funding: The study was funded by Deutsche Forschungsgemeinschaft, German Federal Ministry of Education and Research, German Center for Diabetes Research, European Research Council.Source: Ben Short – Rockefeller University Press Publisher: Organized by NeuroscienceNews.com. Image Source: NeuroscienceNews.com image is credited to Dimitrov et al., 2019. Original Research: Open access research for “Gαs-coupled receptor signaling and sleep regulate integrin activation of human antigen-specific T cells” by Stoyan Dimitrov,Tanja Lange, Cécile Gouttefangeas, Anja T.R. Jensen, Michael Szczepanski, Jannik Lehnnolz, Surjo Soekadar, Hans-Georg Rammensee, Jan Born, and Luciana Besedovsky in Journal of Experimental Medicine. Published February 12 2019. doi:10.1084/jem.20181169See alsoFeaturedNeuroscience·February 18, 2020Discovery at ‘flower burial’ site could unravel mystery of Neanderthal death rites[divider]Cite This NeuroscienceNews.com Article[/divider][cbtabs][cbtab title=”MLA”]Rockefeller University Press”How Sleep Helps to Fight Infection.” NeuroscienceNews. NeuroscienceNews, 12 February 2019. <https://neurosciencenews.com/infection-sleep-10725/>.[/cbtab][cbtab title=”APA”]Rockefeller University Press(2019, February 12). How Sleep Helps to Fight Infection. NeuroscienceNews. Retrieved February 12, 2019 from https://neurosciencenews.com/infection-sleep-10725/[/cbtab][cbtab title=”Chicago”]Rockefeller University Press”How Sleep Helps to Fight Infection.” https://neurosciencenews.com/infection-sleep-10725/ (accessed February 12, 2019).[/cbtab][/cbtabs]AbstractGαs-coupled receptor signaling and sleep regulate integrin activation of human antigen-specific T cellsEfficient T cell responses require the firm adhesion of T cells to their targets, e.g., virus-infected cells, which depends on T cell receptor (TCR)–mediated activation of β2-integrins. Gαs-coupled receptor agonists are known to have immunosuppressive effects, but their impact on TCR-mediated integrin activation is unknown. Using multimers of peptide major histocompatibility complex molecules (pMHC) and of ICAM-1—the ligand of β2-integrins—we show that the Gαs-coupled receptor agonists isoproterenol, epinephrine, norepinephrine, prostaglandin (PG) E2, PGD2, and adenosine strongly inhibit integrin activation on human CMV- and EBV-specific CD8+ T cells in a dose-dependent manner. In contrast, sleep, a natural condition of low levels of Gαs-coupled receptor agonists, up-regulates integrin activation compared with nocturnal wakefulness, a mechanism possibly underlying some of the immune-supportive effects of sleep. The findings are also relevant for several pathologies associated with increased levels of Gαs-coupled receptor agonists (e.g., tumor growth, malaria, hypoxia, stress, and sleep disturbances).[divider]Feel free to share this Neuroscience News.[/divider]Join our Newsletter I agree to have my personal information transferred to AWeber for Neuroscience Newsletter ( more information )Sign up to receive the latest neuroscience headlines and summaries sent to your email daily from NeuroscienceNews.comWe hate spam and only use your email to contact you about newsletters. We do not sell email addresses. You can cancel your subscription any time.