T cells

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T cells

·May 14, 2020

Local inflammatory cells are characteristic for advanced multiple sclerosis

In late-stage multiple sclerosis, inflammatory cells no longer enter the brain via the bloodstream, but instead the cells arise in memory from local memory cells inside the brain. The findings suggest during the late phases of multiple sclerosis, the disease is occurring entirely inside the brain. Read More

Featured Neuroscience Open Neuroscience Articles

·May 5, 2020

Recently recovered COVID-19 patients produce varying virus-specific antibodies

Recovered coronavirus patients show a wide range of immune responses following the infection, with about half from a current study showing sustained antibodies two weeks later. Results indicate which parts of the virus are most effective at triggering the immune responses. Read More

Featured Neuroscience

·May 2, 2020

Temporarily suppressing immune system during early COVID-19 infection may prevent severe symptoms

A new mathematical model examined the immune response in patients with coronavirus. The findings suggest adaptive immune response may kick in before target immune cells are depleted, slowing the infection. The interaction of the innate and adaptive immune response may explain why some with coronavirus experience a second wave infection, appearing to get better before the symptoms return and get worse. Other studies have shown those who received immunosuppressants at the start of infection had a better clinical outcome than those who did not. Read More

Featured Genetics Neuroscience Psychology

·April 21, 2020

Antibodies could provide new treatment for OCD

People with OCD have six times higher Immuno-moodulin (Imood) expression that those without the disorder. Blocking Imood with the aid of an antibody reduced OCD-like behaviors in mouse models within a couple of days following treatment. Read More

Featured Neurology Neuroscience Open Neuroscience Articles

·April 20, 2020

Further evidence autoimmunity plays a role in Parkinson’s disease

T cells that react to alpha-synuclein are most abundant in the early stages of Parkinson's disease but tend to disappear as the disease progresses. Signs of autoimmunity can appear in Parkinson's patients up to ten years before a diagnosis of the neurodegenerative disease. The detection of T cell response could be an early biomarker for Parkinson's, long before the physical symptoms begin to manifest. Read More

Featured Genetics Neuroscience Open Neuroscience Articles

·March 12, 2020

Researchers identify potential targets for immune response to COVID-19

Study provides first potential targets for effective immune responses against COVID-19. The findings provide essential information for vaccine design against SARS-CoV-2. Read More

Featured Genetics Neurology Neuroscience

·February 4, 2020

Dietary interventions may slow onset of inflammatory and autoimmune disorders

Reducing dietary levels of methionine can slow the onset and progression of inflammatory and autoimmune diseases, such as multiple sclerosis, in those with high-risk factors. Read More

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Brain Cancer Featured Genetics Neurology Neuroscience

·January 15, 2020

Scientists breach brain barriers to attack tumors

Introducing VEGF-C into the cerebrospinal fluid of mouse models of glioblastoma, researchers noted increased levels of T cell response to the cancerous tumors. When combined with immune system checkpoint inhibitors, the VEGF-C treatment significantly extended the life span of the mice with glioblastoma brain cancer. Read More

Featured Neurology Neuroscience

·January 8, 2020

Gut microbes may improve stroke recovery

Microbiota-derived short-chain fatty acids (SCFA) modulate stroke recovery. The effect was mediated by circulating lymphocytes on microglia activation. The study reports SCFAs could be a potential therapeutic to improve post-stroke recovery. Read More

Featured Neuroscience Open Neuroscience Articles

·January 5, 2020

Study explains why some creams and cosmetics may cause a skin rash

Study reveals how some chemicals in popular cosmetics and skin lotions displace lipids in skin cells, triggering allergic contact dermatitis. Read More

Featured Genetics Neurology Neuroscience

·January 3, 2020

Fat-dissolving bile acids may help regulate gut immunity and inflammation

Two studies reveal the role bile acids play in immunity and inflammation. Read More

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Featured Neurology Neuroscience

·December 4, 2019

The gut may be involved in the development of multiple sclerosis

Increased levels of Smad7 in T-cells is linked to multiple sclerosis-like symptoms in mice. In the intestines, the T-cells were more frequently activated and migrated to the central nervous system, where they triggered inflammation. Similar activation was seen in human patients with multiple sclerosis. The findings provide further evidence that multiple sclerosis may start in the intestines and spread via the CNS. Read More

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