Blocking the activity of the reactor called the aryl hydrocarbon receptor in T cells resulted in both a decrease in inflammation and recovery in mouse models of multiple sclerosis.
Axicabtagene ciloleucel (axi-cel), a form of CAR-T therapy appears to be safe and has encouraging signs of efficacy in treating both lymphoma of the brain and spinal cord injury.
CAR-T, a therapy generally used in the treatment of cancer, has been shown to eliminate unhealthy cells that trigger autoimmunity in mouse models of multiple-sclerosis.
80% of patients with multiple sclerosis remain disease-free for the long term following an autologous hematopoietic stem cell transplant.
Researchers identified differences in isoforms that control Treg cells and how that affects the body's immune system response.
Excessive glucose consumption directly promotes the pathological function of certain cells within the immune system. Calorie-reduced diets can have beneficial effects on the immune system and have autoimmune diseases.
People with Parkinson's disease have a clear genetic signature of the disease in their memory T-cells.
Infection with the SARS_CoV-2 virus causes dials down the action of olfactory receptors, resulting in smell loss associated with COVID-19.
Researchers found lymph-node-like structures close to glioma brain tumors in cancer patients. The study reveals immune cells within these structures can be activated to attack the brain tumor.
Some of the T cell epitopes targeting myelin in monkeys were the same as those found in humans. Researchers say linking these specific cells opens the doors to developing antiviral therapies that could be useful to treat newly diagnosed cases of MS in humans.
The immune molecule interleukin-17 (Il-17a) appears to influence vigilance and alertness in mouse models. Findings suggest the immune cell affects both brain function and behavior.
When T helper cells are absent in the brain, microglia remain suspended between the fetal and adult developmental state. Mice lacking brain T cells showed changes in behavior and defective synaptic pruning. The study reveals the critical role T cells play in the development of the brain.
