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T cells

Featured Genetics Neuroscience Psychology

·April 21, 2020·3 min read

Antibodies could provide new treatment for OCD

People with OCD have six times higher Immuno-moodulin (Imood) expression that those without the disorder. Blocking Imood with the aid of an antibody reduced OCD-like behaviors in mouse models within a couple of days following treatment.

Featured Neurology Neuroscience Open Neuroscience Articles

·April 20, 2020·4 min read

Further evidence autoimmunity plays a role in Parkinson’s disease

T cells that react to alpha-synuclein are most abundant in the early stages of Parkinson's disease but tend to disappear as the disease progresses. Signs of autoimmunity can appear in Parkinson's patients up to ten years before a diagnosis of the neurodegenerative disease. The detection of T cell response could be an early biomarker for Parkinson's, long before the physical symptoms begin to manifest.

Featured Genetics Neuroscience Open Neuroscience Articles

·March 12, 2020·4 min read

Researchers identify potential targets for immune response to COVID-19

Study provides first potential targets for effective immune responses against COVID-19. The findings provide essential information for vaccine design against SARS-CoV-2.

Featured Genetics Neurology Neuroscience

·February 4, 2020·5 min read

Dietary interventions may slow onset of inflammatory and autoimmune disorders

Reducing dietary levels of methionine can slow the onset and progression of inflammatory and autoimmune diseases, such as multiple sclerosis, in those with high-risk factors.

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Brain Cancer Featured Genetics Neurology Neuroscience

·January 15, 2020·3 min read

Scientists breach brain barriers to attack tumors

Introducing VEGF-C into the cerebrospinal fluid of mouse models of glioblastoma, researchers noted increased levels of T cell response to the cancerous tumors. When combined with immune system checkpoint inhibitors, the VEGF-C treatment significantly extended the life span of the mice with glioblastoma brain cancer.

Featured Neurology Neuroscience

·January 8, 2020·4 min read

Gut microbes may improve stroke recovery

Microbiota-derived short-chain fatty acids (SCFA) modulate stroke recovery. The effect was mediated by circulating lymphocytes on microglia activation. The study reports SCFAs could be a potential therapeutic to improve post-stroke recovery.

Featured Neuroscience Open Neuroscience Articles

·January 5, 2020·5 min read

Study explains why some creams and cosmetics may cause a skin rash

Study reveals how some chemicals in popular cosmetics and skin lotions displace lipids in skin cells, triggering allergic contact dermatitis.

Featured Genetics Neurology Neuroscience

·January 3, 2020·6 min read

Fat-dissolving bile acids may help regulate gut immunity and inflammation

Two studies reveal the role bile acids play in immunity and inflammation.

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Featured Neurology Neuroscience

·December 4, 2019·3 min read

The gut may be involved in the development of multiple sclerosis

Increased levels of Smad7 in T-cells is linked to multiple sclerosis-like symptoms in mice. In the intestines, the T-cells were more frequently activated and migrated to the central nervous system, where they triggered inflammation. Similar activation was seen in human patients with multiple sclerosis. The findings provide further evidence that multiple sclerosis may start in the intestines and spread via the CNS.

Featured Neuroscience Open Neuroscience Articles

·October 14, 2019·4 min read

Gut immunity more developed before birth than previously thought

The fetal gut has far better developed immune capabilities than previously thought. The findings could help develop new maternal vaccines and provide early insight into potential autoimmune disorders, which may occur later in life.

Featured Genetics Neurology Neuroscience

·October 4, 2019·4 min read

Targeting certain rogue T cells prevents and reverses multiple sclerosis: Mouse study

TH17 cells produced increased amounts of SerpinB1, a protein implicated in multiple sclerosis symptoms. SerpinB1 cells were identified with antibodies targeting the CXCR6 surface protein. Using monoclonal antibodies to target CXCR6, the cells disappeared significantly, and the mice primed to develop MS did not develop the disease.