Navigating the Squircle

Summary: Study reveals hippocampal maps predict context-dependent behaviors.

Source: Max Planck Institute

Successful navigation requires the ability to separate memories in a context-dependent manner. For example, to find lost keys, one must first remember whether the keys were left in the kitchen or the office. How does the human brain retrieve the contextual memories that drive behavior?

J.B. Julian of the Princeton Neuroscience Institute at Princeton University, USA, and Christian F. Doeller of the Max Planck Institute for Human Cognitive and Brain Sciences in Leipzig, Germany, found in a recent study that modulation of map-like representations in our brain’s hippocampal formation can predict contextual memory retrieval in an ambiguous environment.

The researchers developed a novel virtual reality navigation task in which human participants learned object positions in two different virtual environments and then had their memory tested during a functional MRI scan.

Memory for object locations was also tested in a third ambiguous context, which the researchers defined as a “squircle” – a cross between a square and a circle. There were no “correct” object positions there; instead, study participants had to rely solely on their memory.

This is an infographic from the study
Cognitive maps in the brain help us to act according to a specific situation. Credit: MPI CBS

“The result of our study confirms the theory, long held by several neuroscientists, that a critical function of the hippocampal formation is to represent the contextual information that guides behavior. Cognitive maps in the brain help us to act according to a specific situation. “, explains Christian Doeller.

Although decades of research indicate that the human hippocampus is critical for contextual memory, no previous studies have linked context-specific signals in this formation of the brain to spatial behavior in a way that clearly separates memory from non-memory factors.

Funding:This research was performed in collaboration with the Kavli Institute for Systems Neuroscience, NTNU, Trondheim, Norway and supported by the European Research Council (ERC-CoG GEOCOG).

About this neuroscience research news

Source: Max Planck Institute
Contact: Bettina Hennebach – Max Planck Institute
Image: The image is credited to MPI CBS

Original Research: Closed access.
Remapping and realignment in the human hippocampal formation predict context-dependent spatial behavior” by Joshua B. Julian & Christian F. Doeller. Nature Neuroscience


Remapping and realignment in the human hippocampal formation predict context-dependent spatial behavior

To guide spatial behavior, the brain must retrieve memories that are appropriately associated with different navigational contexts. Contextual memory might be mediated by cell ensembles in the hippocampal formation that alter their responses to changes in context, processes known as remapping and realignment in the hippocampus and entorhinal cortex, respectively.

However, whether remapping and realignment guide context-dependent spatial behavior is unclear.

To address this issue, human participants learned object–location associations within two distinct virtual reality environments and subsequently had their memory tested during functional MRI (fMRI) scanning.

Entorhinal grid-like representations showed realignment between the two contexts, and coincident changes in fMRI activity patterns consistent with remapping were observed in the hippocampus. Critically, in a third ambiguous context, trial-by-trial remapping and realignment in the hippocampal–entorhinal network predicted context-dependent behavior.

These results reveal the hippocampal–entorhinal mechanisms mediating human contextual memory and suggest that the hippocampal formation plays a key role in spatial behavior under uncertainty.

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