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Summary: Individual differences in the striatum of habitual cannabis users distinguish between who is at increased risk of addiction and cannabis use disorder.
A shift from brain systems controlling reward-driven use to habit-driven use differentiates heavy cannabis users who are addicted to the drug from users who aren’t, according to a study in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. The findings help explain how the brain becomes dependent on cannabis, and why not all cannabis users develop an addiction, even with long-term regular use.
In the study, researchers at the University of Electronic Science and Technology of China and University of Bonn, Germany, used brain imaging to monitor neural activity when cannabis users viewed images associated with cannabis use, referred to as drug cues. Although all of the cannabis users in the study reported heavy use, only some were dependent on the drug. Both dependent and non-dependent cannabis users had exaggerated responses in a brain region that processes reward–the ventral striatum–compared with people who didn’t use cannabis. Interestingly, the dependent users also had larger responses in a brain region that forms habits–the dorsal striatum.
“The present findings reflect that heavy cannabis use is promoted by changes in the brain’s reward system–however, these changes alone may not fully explain addictive use. Addictive use may rather be driven by changes in brain systems that promote habitual–automatic–use, which also may explain the fact that addicts continue use despite a lack of experiencing rewarding effects of the drug. As such, their behavior has become under the control of the drug cues, rather than the actual reward expectation,” said lead author Benjamin Becker, PhD.
Dependent users also had increased responses in other regions throughout the brain, including regions that attribute importance to things, for example, drug cues. This suggests that the development of cannabis addiction incorporates additional brain regions that may strengthen a person’s desire to seek the drug.
“Cannabis is now legal for medical and recreational use in many parts of the United States and the health impacts of this development are still being understood,” said Cameron Carter, MD, Editor of Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. “These findings are important insights that can help us better understand why some individuals might be more likely to become addicted to cannabis,” he added.
Differentiating the unique brain circuits behind dependent cannabis use could also be useful for understanding how to combat the problem of cannabis addiction. “The identification of the dorsal striatum and habitual behavior as a driver of addiction may allow the development of more specific treatment approaches to increase treatment success,” said first author Xinqi Zhou.
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Source: Elsevier Rhiannon Bugno – Elsevier Image Source: The image is in the public domain.
Original Research: Closed access “Cue Reactivity in the Ventral Striatum Characterizes Heavy Cannabis Use, Whereas Reactivity in the Dorsal Striatum Mediates Dependent Use”. Xinqi Zhou, Kaeli Zimmermann, Fei Xin, Weihua Zhao, Roelinka T. Derckx, Anja Sassmannshausen, Dirk Scheele, Rene Hurlemann, Bernd Weber, Keith M. Kendrick,Benjamin Becker. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. doi:10.1016/j.bpsc.2019.04.006
Cue Reactivity in the Ventral Striatum Characterizes Heavy Cannabis Use, Whereas Reactivity in the Dorsal Striatum Mediates Dependent Use
Background Animal models of addiction suggest that the transition from incentive-driven drug use to habitual and ultimately compulsive drug use is mediated by a shift from ventral to dorsal striatal cue control over drug seeking. Previous studies in human cannabis users reported elevated trait impulsivity and neural cue reactivity in striatal circuits; however, these studies were not able to separate addiction-related from exposure-related adaptations.
Methods To differentiate the adaptive changes, the current functional magnetic resonance imaging study examined behavioral and neural cue reactivity in dependent (n = 18) and nondependent (n = 20) heavy cannabis users and a nonusing reference group (n = 44).
Results Irrespective of dependence status, cannabis users demonstrated elevated trait impulsivity as well as increased ventral striatal reactivity and striatal frontal coupling in response to drug cues. Dependent users selectively exhibited dorsal striatal reactivity and decreased striatal limbic coupling during cue exposure. An exploratory analysis revealed that higher ventral caudate neural cue reactivity was associated with stronger cue-induced arousal and craving in dependent users, whereas this pattern was reversed in nondependent users.
Conclusions Taken together, the current findings suggest that exaggerated responses of the ventral striatal reward system may promote excessive drug use in humans, whereas adaptations in dorsal striatal systems engaged in habit formation may promote the transition to addictive use.
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