Twin study suggests genetic factors contribute to insomnia in adults.
A new study of twins suggests that insomnia in adults is partially explained by genetic factors, and this heritability is higher in females than in males.
Results show that the genetic influences on insomnia symptoms in adults were substantial and largely stable over time while differing significantly by sex. In the longitudinal model, the estimated heritability of insomnia was 59 percent for females and 38 percent for males.
“This study indicates that genes may play a larger role in the development of insomnia symptoms for women than for men, providing some of the first formal evidence for sex differences in an adult sample,” said first author Mackenzie Lind, a doctoral candidate at the Virginia Institute for Psychiatric and Behavioral Genetics at Virginia Commonwealth University in Richmond. “Given the evidence for sex differences, it may be useful to specifically target females for sleep interventions.”
Study results are published in the September issue of the journal Sleep.
According to the American Academy of Sleep Medicine, transient insomnia symptoms occur in 30 to 35 percent of the population. Chronic insomnia, which occurs at least three times per week for at least three months, affects about 10 percent of adults. Insomnia is more common in women than men and involves difficulty falling asleep or staying asleep – or regularly waking up earlier than desired – despite an adequate opportunity for sleep.
The VCU research team led by Lind and senior author Ananda B. Amstadter, PhD, analyzed data from the Virginia Adult Twin Studies of Psychiatric and Substance Use Disorders, a large twin data set of approximately 7,500 participants collected by Dr. Kenneth S. Kendler, MD, also an author on this paper. Insomnia symptoms were evaluated via self-report questionnaire at two non-overlapping time points.
According to the authors, this is the first study to examine the genetic and environmental influences on insomnia symptoms in adults in a longitudinal, representative twin sample. The authors also noted that in addition to the substantial heritability estimates, unique environmental factors continue to account for a large amount of variance in insomnia symptoms.
About this genetics research
Funding: The study was supported by grants from the National Institutes of Health (NIH).
Source: Lynn Celmer – American Academy of Sleep Medicine Image Source: The image is in the public domain Original Research:Abstract for “A Longitudinal Twin Study of Insomnia Symptoms in Adults” by Mackenzie J. Lind, BS; Steven H. Aggen, PhD; Robert M. Kirkpatrick, PhD; Kenneth S. Kendler, MD; and Ananda B. Amstadter, PhD in Sleep. Published online August 11 2015 doi:10.5665/sleep.4982
A Longitudinal Twin Study of Insomnia Symptoms in Adults
Twin modeling was used to conduct a genetically informative longitudinal analysis of insomnia symptoms in both sexes.
Data from the Virginia Adult Twin Studies of Psychiatric and Substance Use Disorders (n = 7,500) were used. Past-month insomnia symptoms were assessed at two time points with the shortened version of the Symptom Checklist-90. A composite score for the insomnia items (trouble falling asleep, restless or disturbed sleep, early morning awakenings) was computed. Twin modeling on the composite score was conducted in OpenMx to decompose the phenotypic variance, to examine the longitudinal stability of etiologic influences on insomnia symptoms, and to test for sex differences.
Insomnia symptoms were most commonly endorsed at a mild severity level (composite score mean = 2.24, standard deviation = 2.51). There was no evidence for sex effects in either of the univariate models, and insomnia symptoms were found to be modestly heritable (∼25% at Time 1 and ∼22% at Time 2). In the longitudinal measurement model, which accounts for error of measurement, the heritability for the latent factor of insomnia symptoms increased substantially, and demonstrated quantitative sex differences. The heritability of the latent insomnia factor was ∼59% in females and ∼38% in males.
Genetic factors influence insomnia symptoms in adults, moreso for females than males, and these influences are largely stable over time. When taking into account measurement error, heritability estimates are substantial, but unique environmental factors continue to account for a large amount of variance in insomnia symptoms.
“A Longitudinal Twin Study of Insomnia Symptoms in Adults” by Mackenzie J. Lind, BS; Steven H. Aggen, PhD; Robert M. Kirkpatrick, PhD; Kenneth S. Kendler, MD; and Ananda B. Amstadter, PhD in Sleep. Published online August 11 2015 doi:10.5665/sleep.4982