Poor diet may affect long-term spatial memory

Summary: What you eat may impact your long-term spatial memory. Rats fed a cafeteria-style diet, high in saturated fats and refined carbs, experienced deterioration in spatial memory that was incremental, according to the pattern of access to junk foods.

Source: University of New South Wales

Unhealthy eating may have negative long-term effects on spatial memory, a new study by UNSW researchers suggests.

The animal study, published this week in Scientific Reports, investigated cognitive function in rats that alternated between a ‘cafeteria diet’ of foods high in fat and sugar (like pies, cake, biscuits and chips) and their regular, healthy diet. Over a period of 6 weeks, the rats were fed junk food in intervals of either three, five, or seven consecutive days, separated by their healthy chow diet.

The UNSW researchers found that the rats’ spatial memory recognition deteriorated in increments according to their pattern of access to junk food – the more days in a row they ate junk food, the worse their memory got.

“Anything over three days a week of eating badly impacted memory in these animals,” said Professor Margaret Morris, Head of Pharmacology from the School of Medical Sciences and senior author of the study.

The researchers tested the rats’ spatial memory by first familiarising them with two objects. They then repositioned one of the objects and monitored the rats’ ability to recognise a change in their environment. A healthy animal, Professor Morris explained, would be more likely to explore the object that had been moved.

“We all know that a healthy diet with minimal junk foods is good for our overall health and performance, but this paper shows that it is critical for optimal brain function as well.”

Professor Morris and her team previously showed diet-related changes in rats’ hippocampi, which she explained as the part of the brain responsible for helping us find things and navigate spaces. “This particular brain region is important in all of us,” she said. “It’s also already known to be affected in humans by poor diet.”

In addition to the reduced spatial memory recognition, the study also identified physical differences between rats who consumed the junk food on the three-day and five-day intervals.

The rats who were fed the cafeteria diet on the five-day schedule were considerably heavier, longer and had greater fat mass than those on the three-day schedule. Their metabolic profile also bore a closer resemblance to those on the seven-day schedule than those on the three-day schedule.

Lead author of the paper, Dr Michael Kendig, sees the results as encouraging.

“What it suggests, at least over this relatively short-term study, is that cutting down [an unhealthy diet] even a little bit may have positive effects on cognitive ability,” he said.

“What we’re trying to do is to explore how much an unhealthy diet is likely to damage us,” said Professor Morris. “We want to live and enjoy life, but we do need to temper it with healthy eating most of the time – this study certainly confirms this.”

“What it suggests, at least over this relatively short-term study, is that cutting down [an unhealthy diet] even a little bit may have positive effects on cognitive ability.”

The study adds to existing research on cognitive function and unhealthy diets – but it differs from the body of evidence in important ways. Many existing studies test animals that have unrestrained access to junk food, which doesn’t resemble how junk food is consumed by humans.

“People tend to look at research where animals have had access to junk food 24/7 and might wonder how relevant those results are,” said Dr Kendig. “That’s not really how people eat. We tend to alternate between days or weeks where we eat well and then days or weeks where we eat less well.

This shows a burger

Consuming junk food may have long-term effects on spatial memory. The image is credited to UNSW.

“I think these kinds of experiments where animals have access only some of the time is a better model – I hope this paper starts to add to a more accurate idea of what happens when we eat unhealthily part of the time, not all of the time.”

The researchers said that while the study produced important results, more research was needed before the findings could be translated to humans.

“It is notoriously difficult to do this kind of work in humans, due to ethical concerns,” Professor Morris said. “Getting accurate data on food intake is challenging, but the studies that have been carried out already do point to deficits in executive function in humans eating unhealthily for short periods – and long-term impacts are likely to be greater.”

Funding: This study was funded by a grant from the National Health and Medical Research Council (NHMRC).

About this neuroscience research article

Source:
University of New South Wales
Media Contacts:
Sherry Landow – University of New South Wales
Image Source:
The image is credited to UNSW.

Original Research: Open access
“Pattern of access to cafeteria-style diet determines fat mass and degree of spatial memory impairments in rats”. Michael D. Kendig, R. Frederick Westbrook & Margaret J. Morris.
Scientific Reports doi:10.1038/s41598-019-50113-3.

Abstract

Pattern of access to cafeteria-style diet determines fat mass and degree of spatial memory impairments in rats

Repeated ‘cycling’ between healthy and unhealthy eating is increasingly common but the effects of such cycling on cognitive function are unknown. Here we tested the effects of cycling between chow and a cafeteria diet (CAF) rich in saturated fat and refined carbohydrates on fat mass and place recognition memory in rats. Rats fed the chow diet (control group) were compared with groups fed CAF for either: 3 consecutive days per week followed by 4 days of chow, (3CAF:4CHOW group); 5 consecutive days per week followed by 2 days of chow (5CAF:2CHOW group); or 7 days per week (7CAF group). Total days of exposure to CAF were matched between the latter groups by staggering the introduction of CAF diet. After 16–18 days of CAF, spatial recognition memory was significantly worse in the 7CAF group relative to controls. After 23–25 days of CAF, both the 7CAF and 5CAF:2CHOW groups, but not the 3CAF:4CHOW group, were impaired relative to controls, mirroring changes in fat mass measured by EchoMRI. CAF feeding did not affect object recognition memory or total exploration time. These results indicate that even when matching total exposure, the pattern of access to unhealthy diets impairs spatial memory in a graded fashion.

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