Speech-disrupting brain disease reflects patients’ native tongue

Summary: Language difficulties associated with primary progressive aphasia differ depending on a person’s native language, a new study reports. Native English speakers with PPA have more trouble pronouncing words, while those who speak Italian had fewer pronunciation problems but tend to produce shorter and grammatically simpler sentences.

Source: UCSF

English and Italian speakers with dementia-related language impairment experience distinct kinds of speech and reading difficulties based on features of their native languages, according to new research by scientists at the UC San Francisco Memory and Aging Center and colleagues at the Neuroimaging Research Unit and Neurology Unit at the San Raffaele Scientific Institute in Milan.

Neurologists had long assumed that brain diseases that impact language abilities would manifest in essentially the same way in patients around the world. But recent discoveries have begun to question that assumption. For instance, Italian speakers with dyslexia tend to have less severe reading impairment than English or French speakers due to Italian’s simpler and more phonetic spelling.

“Clinical criteria for diagnosing disorders that affect behavior and language are still mainly based on studies of English speakers and Western cultures, which could lead to misdiagnosis if people who speak different languages or come from another cultural background express symptoms differently,” said study senior author Maria Luisa Gorno-Tempini, MD, PhD, a professor of neurology and psychiatry and the Charles Schwab Distinguished Professor in Dyslexia and Neurodevelopment at the UCSF Memory and Aging Center. “It is critical going forward that studies take language and cultural differences into account when studying brain disorders that affect higher cognitive functions — which we know are greatly impacted by culture, environment, and experience.”

The new study, published January 10, 2020 in Neurology, the medical journal of the American Academy of Neurology, focused on patients with primary progressive aphasia (PPA), a neurodegenerative disorder that affects language areas in the brain, a condition often associated with Alzheimer’s disease, frontotemporal lobar degeneration, and other dementia disorders.

The researchers recruited 20 English-speaking PPA patients from the UCSF Memory and Aging Center and 18 Italian-speaking PPA patients from San Raffaele Hospital, all of whom shared a variant of PPA characterized by difficulty producing or pronouncing words — so-called non-fluent PPA.

“We wanted to study patients with PPA to understand whether people from different language backgrounds actually experienced the disease differently, and what that might mean for how we try to help patients remain resilient to the disease,” said study lead author Elisa Canu, PhD, a neuropsychologist and researcher in the San Raffaele Scientific Institute’s Neuroimaging Research Unit, which is led by co-author Massimo Filippi, MD, full professor of neurology at the affiliated Vita-Salute San Raffaele University, and director of the neurology and neurophysiology units at the San Raffaele Hospital.

Cognitive tests and MRI brain scans revealed similar cognitive function and comparable levels of brain degeneration in the two groups. But when the researchers compared their performance on a battery of linguistic tests, they observed a key difference.

English speakers had more trouble pronouncing words — the traditional hallmark of nonfluent PPA — and tended to speak less than usual. In contrast, Italian speakers with the same disorder had fewer pronunciation difficulties but tended to produce much shorter and grammatically simpler sentences. For example, when asked to describe a drawing of a family at a lake house picnicking and flying a kite, Italian speakers with non-fluent PPA might respond (in Italian): “The man and the woman and the dog”; “Boat in the water”; “Family have picnic”; “There is a kite”.

“We think this is specifically because the consonant clusters that are so common in English pose a challenge for a degenerating speech-planning system,” said Gorno-Tempini, who directs the language neurobiology laboratory at the UCSF Memory and Aging Center, and is co-director of the UCSF Dyslexia Center and the recently launched UCSF-UC Berkeley Schwab Dyslexia and Cognitive Diversity Center. “In contrast, Italian is easier to pronounce, but has much more complex grammar, and this is how Italian speakers with PPA tend to run into trouble.”

This shows two heads
English speakers had more trouble pronouncing words — the traditional hallmark of nonfluent PPA — and tended to speak less than usual. In contrast, Italian speakers with the same disorder had fewer pronunciation difficulties but tended to produce much shorter and grammatically simpler sentences. Image is in the public domain.

The results are important for efforts to ensure accurate diagnoses for patients with PPA across different cultures: in the current study the Italian speakers do not match the established diagnostic criteria for nonfluent PPA as closely as the English speakers, since the criteria are based on studies of English-speaking patients.

“This means that there are probably many people around the world — including non-native English speakers in the U.S. — who are not getting the right diagnosis because their symptoms don’t match what is described in clinical manuals based on studies of native English speakers,” said Gorno-Tempini.

The researchers acknowledge that this is a small study and cannot completely exclude the possibility that differences in dementia severity, undetected anatomical differences and differences in education level between Italian and English participants could be confounding factors in the results.

Future studies in partnership with the Global Brain Health Institute (GBHI), a joint effort of UCSF and Trinity College Dublin to reduce the impact of dementia around the world, will attempt to replicate the findings in larger groups of patients, and look for further differences between speakers of even more diverse, non-Western languages, such as Chinese and Arabic.

“We hope that such studies will advance our understanding of the brain science underlying language and language disorders, raise awareness of health disparities in dementia treatment, and ultimately improve care for all patients,” Gorno-Tempini said.

Funding: This study has been supported by the U.S. National Institutes of Health (NINDS R01 NS050915; NIDCD K24 DC015544; NIAU01 AG052943; NIA P50 AG023501; NIA P01 AG019724), the Italian Ministry of Health (GR-2010-2303035; GR-2011-02351217), the Alzheimer’s Disease Center of California (03-75271 DHS/ADP/ARCC), the Larry L. Hillblom Foundation, the John Douglas French Alzheimer’s Foundation, the Koret Family Foundation, the Consortium for Frontotemporal Dementia Research, and the McBean Family Foundation.

Disclosures: See study online for listing of potential conflict of interest disclosures.

About this neuroscience research article

Source:
UCSF
Media Contacts:
Nicholas Weiler – UCSF
Image Source:
The image is in the public domain.

Original Research: Closed access
“Speech production differences in English and Italian speakers with nonfluent variant PPA”. Elisa Canu, Federica Agosta, Giovanni Battistella, Edoardo G. Spinelli, Jessica DeLeon, Ariane E. Welch, Maria Luisa Mandelli, H. Isabel Hubbard, Andrea Moro, Giuseppe Magnani, Stefano F. Cappa, Bruce L. Miller, Massimo Filippi, Maria Luisa Gorno-Tempini.
Neurology doi:10.1212/WNL.0000000000008879.

Abstract

Speech production differences in English and Italian speakers with nonfluent variant PPA

Objective
To understand whether the clinical phenotype of nonfluent/agrammatic primary progressive aphasia (nfvPPA) could present differences depending on the patient’s native language.

Methods
In this cross-sectional study, we analyzed connected speech samples in monolingual English (nfvPPA-E) and Italian speakers (nfvPPA-I) who were diagnosed with nfvPPA and matched for age, sex, and Mini-Mental State Examination scores. Patients also received a comprehensive neuropsychological battery. All patients and 2 groups of age-matched healthy controls underwent an MRI scan with 3D T1-weighted sequences. Connected speech measures and the other cognitive features were compared between patient groups. MRI variables, in terms of gray matter volume, were compared between each patient group and the corresponding controls.

Results
Compared to nfvPPA-E, nfvPPA-I had fewer years of education and shorter reported disease duration. The 2 groups showed similar regional atrophy compatible with clinical diagnosis. Patients did not differ in nonlanguage domains, comprising executive scores. Connected speech sample analysis showed that nfvPPA-E had significantly more distortions than nfvPPA-I, while nfvPPA-I showed reduced scores in some measures of syntactic complexity. On language measures, Italian speakers performed more poorly on syntactic comprehension.

Conclusions
nfvPPA-E showed greater motor speech impairment than nfvPPA-I despite higher level of education and comparable disease severity and atrophy changes. The data also suggest greater grammatical impairment in nfvPPA-I. This study illustrates the need to take into account the possible effect of the individual’s spoken language on the phenotype and clinical presentation of primary progressive aphasia variants.

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