Neuroscience research articles are provided.
What is neuroscience? Neuroscience is the scientific study of nervous systems. Neuroscience can involve research from many branches of science including those involving neurology, brain science, neurobiology, psychology, computer science, artificial intelligence, statistics, prosthetics, neuroimaging, engineering, medicine, physics, mathematics, pharmacology, electrophysiology, biology, robotics and technology.
– These articles focus mainly on neurology research. – What is neurology? – Definition of neurology: a science involved in the study of the nervous systems, especially of the diseases and disorders affecting them. – Neurology research can include information involving brain research, neurological disorders, medicine, brain cancer, peripheral nervous systems, central nervous systems, nerve damage, brain tumors, seizures, neurosurgery, electrophysiology, BMI, brain injuries, paralysis and spinal cord treatments.
What is Psychology? Definition of Psychology: Psychology is the study of behavior in an individual, or group. Psychology news articles are listed below.
Artificial Intelligence articles involve programming, neural engineering, artificial neural networks, artificial life, a-life, floyds, boids, emergence, machine learning, neuralbots, neuralrobotics, computational neuroscience and more involving A.I. research.
Robotics articles will cover robotics research press releases. Robotics news from universities, labs, researchers, engineers, students, high schools, conventions, competitions and more are posted and welcome.
Genetics articles related to neuroscience research will be listed here.
Neurotechnology research articles deal with robotics, AI, deep learning, machine learning, Brain Computer Interfaces, neuroprosthetics, neural implants and more. Read the latest neurotech news articles below.
Before the fluid of the middle ear drains and sound waves penetrate for the first time, the inner ear cells of newborn rodents practice for their big debut. Researchers at Johns Hopkins report they have figured out the molecular chain of events that enables the cells to make “sounds” on their own, essentially “practicing” their ability to process sounds in the world around them.
The researchers, who describe their experiments in the Dec. 3 edition of the journal Cell, show how hair cells in the inner ear can be activated in the absence of sound. “The multistep process we uncovered reminds me of a Rube Goldberg invention,” says Dwight Bergles, Ph.D., professor of neuroscience at the Johns Hopkins University School of Medicine, a reference to Goldberg’s construction of complicated gadgets to perform seemingly simple tasks. “Cells in the inner ear exploit a system used for fluid secretion in other organs to simulate the effect of sound before hearing begins, preparing them for the real deal.”
Normal hearing in most mammals, Bergles says, is a multistep process that begins with sound waves hitting the ear drum, which transfers energy to the air-filled middle ear and its three tiny bones. Then the fluid in the inner ear vibrates at a corresponding electrical frequency, which bends the “antennas” of just the right “hair cells,” causing them to release chemical messengers that tell nearby nerves to fire. That signal then travels to the brain, where it is interpreted as a particular sound.
Scientists, Bergles says, already knew that hair cells and nearby “supporting” cells in the developing inner ear show synchronous bursts of activity that are triggered by release of the “energy” chemical ATP, which is also used as a potent communication signal. This activity is then conveyed to the brain in the same way that sound-evoked information is, leading to burst firing of neurons in different auditory centers of the brain. What was unknown was how ATP activates hair cells.
To find out, Bergles and his team homed in on biochemical elements of the system and found that chloride ion channels in the supporting cells seemed crucial. They knew that ATP triggers a rise in calcium levels inside supporting cells, so they guessed that the calcium was the cue for a calcium-activated chloride channel to open.
An analysis of gene activity in the supporting cells pointed to involvement of the TMEM16A chloride channel, and they found high levels of this channel within supporting cells that surround inner hair cells. Experiments in mice revealed that when this channel was removed from supporting cells or blocked with drugs, the spontaneous excitation of the hair cells decreased.
Further biochemical tests, combined with electrical recordings and imaging of calcium changes in the inner ears of mice, allowed the team to piece together a full chain of events. First, supporting cells release ATP, leading to self-stimulation of their own ATP receptors, triggering an increase in calcium levels inside the cells. This rise in calcium opens the TMEM16A channels to let chloride out, which also drags potassium ions and water out. The potassium that is released during these events activates the hair cells, stimulating the nerve cells with which they have formed weak connections.
It’s this pairing, says Bergles, that is thought to stabilize connections that help the brain make sense of sounds. “This step happens during the first two weeks after birth in mice and rats, when the middle ear is still filled with fluid and outside sounds can’t reach the inner ear.”
He adds: “The hair cells are arranged in a line and respond to different frequencies based on their location, like keys on a piano. Their connection with nearby nerve cells is strengthened every time a hair cell is activated and causes its partner nerve cell to fire.” When the brain receives a signal from hair cells near the entrance of the inner ear, he says, it “hears” a high-pitched sound; when the signal comes from farther in, it “hears” a deeper sound.
“There’s a beauty to this seemingly overly complex process,” Bergles says. “It uses the capabilities of the cells in a novel way to trigger nerve cell activity. We think this helps establish and refine the connections between ear and brain so that the animals can properly hear sounds as soon as they are exposed to them.”
Because mice can’t tell researchers if they are hearing anything, researchers can only surmise that they do based on activity they record in the auditory centers of the brain. Bergles says their research suggests that these “sounds” might be perceived as single tones played in succession, something like tests of an emergency response system. He says that the self-made sounds are for the ear what a batting machine is for a baseball player. “The machines don’t have all the richness and unpredictability of a pitcher throwing a ball, but they nevertheless help players prepare for the big event.”
Although this self-stimulation process disappears after hearing begins, Bergles says that if this pathway were reactivated following injury, it could lead to tinnitus, or “ringing” in the ear. Further understanding of this early signaling, he says, may lead to new strategies for improving the integration and performance of cochlear implants and speeding recovery from sound-induced trauma.
[divider]About this auditory neuroscience research[/divider]
Other authors of the report include Han Chin Wang, Chun-Chieh Lin, Rocky Cheung, YingXin Zhang-Hooks and Amit Agarwal of the Johns Hopkins University School of Medicine; Graham Ellis-Davies of the Icahn School of Medicine at Mount Sinai; and Jason Rock of the University of California, San Francisco.
Funding: Funded by the NIH/National Institute of Neurological Disorders and Stroke, NIH/National Institute of Mental Health, NIH/National Institute on Deafness and other Communication Disorders, and NIH/National Institute of General Medical Sciences.
Source: Shawna Williams – Johns Hopkins Medicine Image Source: The image is credited to Han Chin Wang and Dwight E. Bergles Original Research: Abstract for “Spontaneous Activity of Cochlear Hair Cells Triggered by Fluid Secretion Mechanism in Adjacent Support Cells” by Han Chin Wang, Chun-Chieh Lin, Rocky Cheung, YingXin Zhang-Hooks, Amit Agarwal, Graham Ellis-Davies, Jason Rock, and Dwight E. Bergles in Cell. Published online October 19 2015 doi:10.1016/j.cell.2015.10.070
Spontaneous Activity of Cochlear Hair Cells Triggered by Fluid Secretion Mechanism in Adjacent Support Cells
Highlights •Inner supporting cells (ISCs) in the developing cochlea express TMEM16A Cl− channels •Spontaneous currents in ISCs reflect purinergic receptor-mediated gating of TMEM16A •Cl− efflux through TMEM16A induces K+ release, which depolarizes inner hair cells •Spontaneous activity of hair cells and ganglion neurons is reduced in Tmem16a KO mice
Summary Spontaneous electrical activity of neurons in developing sensory systems promotes their maturation and proper connectivity. In the auditory system, spontaneous activity of cochlear inner hair cells (IHCs) is initiated by the release of ATP from glia-like inner supporting cells (ISCs), facilitating maturation of central pathways before hearing onset. Here, we find that ATP stimulates purinergic autoreceptors in ISCs, triggering Cl− efflux and osmotic cell shrinkage by opening TMEM16A Ca2+-activated Cl− channels. Release of Cl− from ISCs also forces K+ efflux, causing transient depolarization of IHCs near ATP release sites. Genetic deletion of TMEM16A markedly reduces the spontaneous activity of IHCs and spiral ganglion neurons in the developing cochlea and prevents ATP-dependent shrinkage of supporting cells. These results indicate that supporting cells in the developing cochlea have adapted a pathway used for fluid secretion in other organs to induce periodic excitation of hair cells.
“Spontaneous Activity of Cochlear Hair Cells Triggered by Fluid Secretion Mechanism in Adjacent Support Cells” by Han Chin Wang, Chun-Chieh Lin, Rocky Cheung, YingXin Zhang-Hooks, Amit Agarwal, Graham Ellis-Davies, Jason Rock, and Dwight E. Bergles in Cell. Published online October 19 2015 doi:10.1016/j.cell.2015.10.070
[divider]Feel free to share this neuroscience article.[/divider]