New Study Identifies Plasticity Disparities Between Patients With Brain Malformation

Summary: Patients with Corpus Callosum Dysgenesis (CCD), a genetic condition marked by incomplete development of the connecting structures between the brain hemispheres, have distinct reconfiguration of their neural connections, researchers report.

Source: D’Or Institute for Research and Education

Recently published in the scientific journal Brain Communications, a new study distinguished structural patterns between individuals with corpus callosum dysgenesis (CCD), a congenital condition that consists of the absence or incomplete development in the connecting structure between the two brain hemispheres.

The research was carried out by the D’Or Institute for Research and Education (IDOR), the University of Pittsburgh, Oswaldo Cruz Foundation (Fiocruz), and the Federal University of Rio de Janeiro (UFRJ).

Investigating CCD is an arduous task for doctors and neuroscientists. There aren’t many patients available for research, and the anatomical variability of brains with CCD creates a broad clinical spectrum. Due to brain plasticity – the organ’s ability to create alternative connections to ensure its functioning in adverse situations -, the clinical scenario range from the complete lack of symptoms to epilepsy and psychomotor retardation, in addition to being commonly found in autism spectrum disorder.

“The CCD is one of the greatest mysteries of neuroscience. To this day, researchers don’t fully know how this neuroplasticity occurs. But we’ve had new discoveries in the past years, mainly through in vivo methods that analyze these patients’ brain connections via imaging”, informs the study’s corresponding author, Dr. Fernanda Tovar-Moll, M.D., radiologist and president of IDOR.

Considering the challenges presented by this pathological plurality, the study’s researchers analyzed the structural and neurological alterations of 11 patients with CCD, men and women aged from 4 to 33 years old. Of these, 6 had a complete absence of the corpus callosum (agenesis) and the other 5 were characterized by its hypoplasia, which is the underdevelopment of the structure.

The research was carried out through functional and structural magnetic resonance imaging. The images were first evaluated by a neuroradiologist to confirm the diagnosis of CCD and then were examined again to map the patients’ neural connections, which were compared with a control group composed of 45 healthy individuals.

As expected, the results showed that structural connectivity in individuals with agenesis or hypoplasia of the corpus callosum differed from the images in the control group. However, clear differences were also noted within the groups with CCD. 

Despite having fewer connections when compared to the other two groups, patients with agenesis connected brain regions in a functionally similar way to healthy patients, while individuals with hypoplasia showed a broader, but abnormal and variant reorganization between brain connections, which would justify the worsening of symptoms in patients with this type of CCD.

This is a diagram from the study
Graphs display axial views of the brain with lines depicting the edges. Blue edges represent missing connections, and orange and gray edges indicate aberrant connections in every individual of CA and HP subjects, respectively. The graphs in A and B show the comparison of callosal agenesis (CA) and hypoplasic (HP) patients with healthy controls (CT), respectively. The graph in C shows the comparison between the two different CCD phenotypes. Green shows the connections present only in HP and black only in CA. The bar plots below show the quantification of the number of edges. CT = Controls, CA = Corpus Callosum Agenesis, and HP = Hypoplasia, Intra = intrahemispheric, Inter = interhemispheric. Credit: Diego Szczpak

“The hypoplastic corpus callosum usually connects regions of the brain that it shouldn’t connect. Instead of positive neuroplasticity, this characteristic could be the cause of symptoms”, explains Diego Szczupak, Ph.D. and the study’s first author.

Although previous studies have already described the anatomical heterogeneity in brains with CCD, the different types of dysgenesis have not yet been widely compared to each other, and the distinctions between their adaptive brain plasticity are still unfamiliar.

These findings show that the hypoplasia and agenesis in CCD have unique fingerprints and use distinct plastic mechanisms to compensate for the partial or complete lack of the corpus callosum. But the authors emphasize that this does not necessarily mean that the coherence, speed, and precision of these connections reflect the same brain functioning as in healthy individuals.

Dr. Fernanda Tovar-Moll is also part of an international research consortium, the IRC5, whose mission is to discover the causes, consequences, and possible interventions for corpus callosum dysgenesis and associated brain connectivity disorders. From June 27th to July 1st, IDOR is organizing an IRC5 meeting addressed to family members, doctors, neuroscientists, and psychologists interested in the topic. 

About this neuroplasticity research news

Source: D’Or Institute for Research and Education
Contact: Maria Eduarda Ledo – D’Or Institute for Research and Education
Image: The image is credited to Diego Szczpak

Original Research: Open access.
Corpus callosum dysgenesis causes novel patterns of structural and functional brain connectivity” by Diego Szczpak et al. Brain Communications


Corpus callosum dysgenesis causes novel patterns of structural and functional brain connectivity

Developmental malformations (dysgenesis) of the corpus callosum lead to neurological conditions with a broad range of clinical presentations. Investigating the altered brain connectivity patterns is crucial to understanding both adaptive and maladaptive neuroplasticity in corpus callosum dysgenesis patients.

Here, we acquired structural diffusion-weighted and resting-state functional MRI data from a cohort of 11 corpus callosum dysgenesis patients (5 with agenesis and 6 with hypoplasia) and compared their structural and functional connectivity patterns to healthy subjects selected from the Human Connectome Project.

We found that these patients have fewer structural inter and intrahemispheric brain connections relative to healthy controls. Interestingly, the patients with callosal agenesis have a scant number of interhemispheric connections but manage to maintain the full integrity of functional connectivity between the same cortical regions as the healthy subjects.

On the other hand, the hypoplasic group presented abnormal structural and functional connectivity patterns relative to healthy controls while maintaining the same total amount of functional connections. These results demonstrate that acallosal patients can compensate for having fewer structural brain connections and present functional adaptation.

However, hypoplasics present atypical structural connections to different brain regions, leading to entirely new and abnormal functional brain connectivity patterns.

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