Cholesterol and fat profiles at birth linked to psychological health at age 5

Summary: Children born with high levels of triglycerides and low-density lipoprotein in their cord blood samples were more likely to receive lower ratings from their teachers on both social and emotional development scales.

Source: APS

Babies born with high levels of bad cholesterol and a certain type of fat may face a heightened risk for social and psychological problems in childhood, according to new scientific findings.

In a study involving 1,369 children tracked from birth to 5 years of age, psychological scientists found that results of a standard blood test taken at birth could predict how teachers rated the children on emotion regulation, self-awareness, and interpersonal behavior 5 years later.

The results are published in Psychological Sciencee.

Researchers Erika M. Manczak of the University of Denver and Ian Gotlib of Stanford University were specifically interested in looking at the long-term implications of infants’ lipid profiles — a measurement of the amount of cholesterol and triglycerides in the blood. Triglycerides are fats that, at high levels, can increase the risk of stroke and heart disease.

Manczak and Gotlib used data from an ongoing study involving children born in the town of Bradford in the United Kingdom between March 2007 and December 2010. They looked at data involving 1,369 children from birth to 5 years of age. The babies were born to mothers of various ethnic backgrounds.

When the children reached age 3, the mothers were asked to rate their child’s health. And when the children were 4 to 5 years old, their teachers rated each of them on their psychological development, including self-confidence, emotional control, and interpersonal relationships. The teachers were asked to classify each child as below, at, or exceeding developmental expectations.

Manczak and Gotlib found that newborns’s whose cord blood showed high levels of high-density lipoprotein (HDL)–known as the “good cholesterol” because it removes fat from artery walls–were significantly more likely to later receive higher ratings on psychological development by their teachers. In contrast, newborns whose cord blood tested high for triglycerides and very-low-density lipoprotein–known as the bad cholesterol–were more likely to receive low teacher ratings on social and emotional development. The results were consistent across ethnic groups and gender.

This shows a baby

Manczak and Gotlib found that newborns’s whose cord blood showed high levels of high-density lipoprotein (HDL)–known as the “good cholesterol” because it removes fat from artery walls–were significantly more likely to later receive higher ratings on psychological development by their teachers. The image is in the public domain.

Manczak and Gotlib acknowledge that their findings are correlational and don’t conclusively show that lipids in cord blood lead to psychological problems over time. But the results do introduce the possibility that lipids may be a new mechanism to consider when trying to understand the causes of mental health problems, they say.

“If this is replicated in other studies, it would suggest that lipid profiles at birth could play a role in identifying children who might be at heightened risk for psychological problems later, allowing health care providers to intervene early,” Manczak says. “It also introduces the possibility that lipids may be a new mechanism to consider when trying to understand what causes mental health problems.”

About this neuroscience research article

Source:
APS
Media Contacts:
Scott Sleek – APS
Image Source:
The image is in the public domain.

Original Research: Closed access
“Lipid Profiles at Birth Predict Teacher-Rated Child Emotional and Social Development 5 Years Later”. Erika M. Manczak, Ian H. Gotlib.
Psychological Science doi:10.1177/0956797619885649.

Abstract

Lipid Profiles at Birth Predict Teacher-Rated Child Emotional and Social Development 5 Years Later

The fetal environment has been increasingly implicated in later psychological health, but the role of lipids is unknown. Drawing on the ethnically diverse Born in Bradford (BiB) birth cohort, the current study related levels of high-density lipoprotein (HDL), very-low-density lipoprotein (VLDL), and triglycerides in umbilical cord blood to 1,369 children’s teacher-rated psychosocial competence approximately 5 years later. Results of ordinal logistic regressions indicated that low levels of HDL, high levels of VLDL, and high levels of triglycerides predicted greater likelihood of being rated as less competent in domains of emotion regulation, self-awareness, and interpersonal functioning. Furthermore, these results generalized across ethnic background and children’s sex and were not accounted for by variables reflecting mothers’ psychological or physical health, children’s physical health, or children’s special education status. Together, these results identify fetal exposure to anomalous lipid levels as a possible contributor to subsequent psychological health and social functioning.

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