A new study shows significant differences in brain development in high-risk infants who develop autism starting as early as age 6 months. The findings published in the American Journal of Psychiatry reveal that this abnormal brain development may be detected before the appearance of autism symptoms in an infant’s first year of life. Autism is typically diagnosed around the age of 2 or 3.
The study offers new clues for early diagnosis, which is key, as research suggests that the symptoms of autism – problems with communication, social interaction and behavior – can improve with early intervention. “For the first time, we have an encouraging finding that enables the possibility of developing autism risk biomarkers prior to the appearance of symptoms, and in advance of our current ability to diagnose autism,” says co-investigator Dr. Alan Evans at the Montreal Neurological Institute and Hospital – the Neuro, McGill University, which is the Data Coordinating Centre for the study.
“Infancy is a time when the brain is being organized and connections are developing rapidly,” says Dr. Evans. “Our international research team was able to detect differences in the wiring by six months of age in those children who went on to develop autism. The difference between high-risk infants that developed autism and those that did not was specifically in white matter tract development – fibre pathways that connect brain regions.” The study followed 92 infants from 6 months to age 2. All were considered at high-risk for autism, as they had older siblings with the developmental disorder. Each infant had a special type of MRI scan, known as diffusion tensor imaging, at 6 months and a behavioral assessment at 24 months. The majority also had additional scans at either or both 12 and 24 months.
At 24 months, 30% of infants in the study were diagnosed with autism. White matter tract development for 12 of the 15 tracts examined differed significantly between the infants that developed autism and those who did not. Researchers evaluated fractional anisotropy (FA), a measure of white matter organization based on the movement of water through tissue. Differences in FA values were greatest at 6 and 24 months. Early in the study, infants who developed autism showed elevated FA values along these tracts, which decreased over time, so that by 24 months autistic infants had lower FA values than infants without autism.
The study characterizes the dynamic age-related brain and behavior changes underlying autism – vital for developing tools to aid autistic children and their families. This is the latest finding from the on-going Infant Brain Imaging Study (IBIS), which is funded by the National Institutes of Health (NIH) and brings together the expertise of a network of researchers from institutes across North America. The IBIS study is headquartered at the University of North Carolina, and The Neuro is the Data Coordinating Centre where all IBIS data is centralized.
The IBIS Network is supported by the NIH, Autism Speaks and the Simons Foundation.
Contact: Montreal Neurological Institute and Hospital media Source: Montreal Neurological Institute and Hospital press release Image Source: Brain image adapted from MNI at McGill University press release image Original Research: Abstract for “Differences in White Matter Fiber Tract Development Present From 6 to 24 Months in Infants With Autism” by Jason J. Wolff, Ph.D.; Hongbin Gu, Ph.D.; Guido Gerig, Ph.D.; Jed T. Elison, Ph.D.; Martin Styner, Ph.D.; Sylvain Gouttard, M.S.; Kelly N. Botteron, M.D.; Stephen R. Dager, M.D.; Geraldine Dawson, Ph.D.; Annette M. Estes, Ph.D.; Alan C. Evans, Ph.D.; Heather C. Hazlett, Ph.D.; Penelope Kostopoulos, Ph.D.; Robert C. McKinstry, M.D., Ph.D.; Sarah J. Paterson, Ph.D.; Robert T. Schultz, Ph.D.; Lonnie Zwaigenbaum, M.D.; Joseph Piven, M.D.; the IBIS Network in American Journal of Psychiatry June 2012 169:589-600 doi: 10.1176/appi.ajp.2011.11091447